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Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2) : a randomised, parallel group, open-label trial

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dc.contributor.authorMuir, Keith W
dc.contributor.authorFord, Gary A
dc.contributor.authorFord, Ian
dc.contributor.authorWardlaw, Joanna M
dc.contributor.authorMcConnachie, Alex
dc.contributor.authorGreenlaw, Nicola
dc.contributor.authorMair, Grant
dc.contributor.authorSprigg, Nikola
dc.contributor.authorPrice, Christopher I
dc.contributor.authorMacLeod, Mary Joan
dc.contributor.authorDima, Sofia
dc.contributor.authorVenter, Marius
dc.contributor.authorZhang, Liqun
dc.contributor.authorO’Brien, Eoin
dc.contributor.authorSanyal, Ranjan
dc.contributor.authorReid, John
dc.contributor.authorSztriha, Laszlo K
dc.contributor.authorHaider, Syed
dc.contributor.authorWhiteley, William N
dc.contributor.authorKennedy, James
dc.contributor.authorPerry, Richard
dc.contributor.authorLakshmanan, Sekaran
dc.contributor.authorChakrabarti, Annie
dc.contributor.authorHassan, Ahamad
dc.contributor.authorMarigold, Richard
dc.contributor.authorRaghunathan, Senthil
dc.contributor.authorSims, Don
dc.contributor.authorBhandari, Mohit
dc.contributor.authorWiggam, Ivan
dc.contributor.authorRashed, Khalid
dc.contributor.authorDouglass, Chris
dc.contributor.authorATTEST-2 Investigators
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.date.accessioned2024-10-18T10:23:01Z
dc.date.available2024-10-18T10:23:01Z
dc.date.issued2024-11-30
dc.descriptionAcknowledgments The trial was funded by the Stroke Association and British Heart Foundation (grant reference numbers TSA BHF 2015/01 and CS/15/8/32065). Tenecteplase was supplied free of charge by Boehringer Ingelheim. We thank the following individuals: on the Independent Data Monitoring Committee: Richard Lindley (Chair), Graeme MacLennan, and Charlotte Cordonnier. We acknowledge the contributions of key trial support team members: Shirley Mitchell (trial management); Mairi Warren (project and trial management); Alicia Murray (trial management); Angela Welch, Wilma Smith, Emma MacRae, and Wendy Jackson (central outcome assessment); Kirsty Wetherall (statistical checking); John McHugh (database manager); Jane Aziz, Christopher Graham, and Robbie Wilson (electronic data capture and randomisation systems development); Eleni Sakka (imaging database management); Jeb Palmer (University of Edinburgh Systematic Image Review Service oversight); David Perry and David Buchanan (scan housekeeping system); and Lesley Cala, Daisy Mollison, and Elena Boyd (scan reading).en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent650946
dc.identifier297859048
dc.identifier056bdfd4-5ca1-46d9-9d38-49d348d9eaf7
dc.identifier85206342688
dc.identifier39424558
dc.identifier.citationMuir, K W, Ford, G A, Ford, I, Wardlaw, J M, McConnachie, A, Greenlaw, N, Mair, G, Sprigg, N, Price, C I, MacLeod, M J, Dima, S, Venter, M, Zhang, L, O’Brien, E, Sanyal, R, Reid, J, Sztriha, L K, Haider, S, Whiteley, W N, Kennedy, J, Perry, R, Lakshmanan, S, Chakrabarti, A, Hassan, A, Marigold, R, Raghunathan, S, Sims, D, Bhandari, M, Wiggam, I, Rashed, K, Douglass, C & ATTEST-2 Investigators 2024, 'Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2) : a randomised, parallel group, open-label trial', The Lancet neurology, vol. 23, no. 11, pp. 1087-1096. https://doi.org/10.1016/S1474-4422(24)00377-6en
dc.identifier.doi10.1016/S1474-4422(24)00377-6
dc.identifier.iss11en
dc.identifier.issn1474-4422
dc.identifier.otherBibtex: MUIR20241087
dc.identifier.otherORCID: /0000-0003-2115-8184/work/170010490
dc.identifier.urihttps://hdl.handle.net/2164/24433
dc.identifier.vol23en
dc.language.isoeng
dc.relation.ispartofThe Lancet neurologyen
dc.subjectSubstantive connection via an eligible employment contracten
dc.subjectR Medicineen
dc.subjectOtheren
dc.subjectCS/15/8/32065en
dc.subjectTSA BHF 2015/01en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleTenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2) : a randomised, parallel group, open-label trialen
dc.typeJournal articleen

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