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An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome

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dc.contributor.authorHay, Elizabeth Anne
dc.contributor.authorKhalaf, Abdulla Razak
dc.contributor.authorMarini, Pietro
dc.contributor.authorBrown, Andrew
dc.contributor.authorHeath, Karyn
dc.contributor.authorSheppard, Darrin
dc.contributor.authorMacKenzie, Alasdair
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.date.accessioned2016-11-30T13:28:20Z
dc.date.available2016-11-30T13:28:20Z
dc.date.issued2017-08
dc.descriptionAcknowledgements These studies were funded by a Wellcome Trust (105625/Z/14/Z) ISSF starting grant, Medical Research Scotland (PhD-719-2013) and GW Pharmaceuticals (PhD-719-2013 - S.5242.001).en
dc.description.statusPeer revieweden
dc.format.extent7
dc.format.extent1487184
dc.identifier73235151
dc.identifierf19aae0c-77ab-493e-b412-deff773220aa
dc.identifier27866656
dc.identifier85006804245
dc.identifier.citationHay, E A, Khalaf, A R, Marini, P, Brown, A, Heath, K, Sheppard, D & MacKenzie, A 2017, 'An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome', Neuropeptides, vol. 64, pp. 101-107. https://doi.org/10.1016/j.npep.2016.11.003en
dc.identifier.doi10.1016/j.npep.2016.11.003
dc.identifier.issn0143-4179
dc.identifier.otherORCID: /0000-0002-8456-4473/work/177758657
dc.identifier.urihttp://hdl.handle.net/2164/7773
dc.identifier.vol64en
dc.language.isoeng
dc.relation.ispartofNeuropeptidesen
dc.subjectneuropeptideen
dc.subjectenhanceren
dc.subjectCAS9/CRISPRen
dc.subjectOff-target effectsen
dc.subjecttransgenic mouseen
dc.subjectCAS9 mRNAen
dc.subjectgRNAen
dc.subject1-cell mouse embryoen
dc.subjectCytoplasmic microinjectionen
dc.subjectCRISPR design toolen
dc.subjectUCSC browser BLATen
dc.subjectPCRen
dc.subjectSanger sequencingen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subject105625/Z/14/Zen
dc.subject.lccRen
dc.titleAn analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genomeen
dc.typeJournal articleen

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