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Characterization of a Cul9–Parkin double knockout mouse model for Parkinson’s disease

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dc.contributor.authorHollville, Emilie
dc.contributor.authorJoers, Valerie
dc.contributor.authorNakamura, Ayumi
dc.contributor.authorSwahari, Vijay
dc.contributor.authorTansey, Malú G.
dc.contributor.authorMoy, Sheryl S.
dc.contributor.authorDeshmukh, Mohanish
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2023-03-08T12:01:01Z
dc.date.available2023-03-08T12:01:01Z
dc.date.issued2020
dc.descriptionAcknowledgements We thank Viktoriya Nikolova at the UNC Mouse Behavioural Phenotyping Laboratory for her technical assistance. This work was supported by a Rapid Response Innovation Award (ID 9056) from the Michael J Fox Foundation for Parkinson’s Research and by the NIH Grant GM118331 to M.D. V.J. was supported by Training in translational Research in Neurology NIH Fellowship 2T32NS007480. The Tansey laboratory is supported by NIH/NIA 1R01 AG057247, NIH/NINDS 5R01 NS092122, NIH/NIA 3RF1 AG051514-01, and the Norman Fixel Institute for Neurological Diseases to M.G.T. The UNC Mouse Behavioural Phenotyping Laboratory is supported by a grant from the National Institute of Child Health and Human Development (NICHD), U54-HD079124. The Neuroscience Microscopy Core Facility is supported, in part, by funding from the NIH-NINDS Neuroscience Center Support Grant P30 NS045892 and the NIH-NICHD Intellectual and Developmental Disabilities Research Center Support Grant U54 HD079124. Contributions E.H. conducted the in vitro experiments and prepared the mice cohorts. V.S. and A.N. helped with generating the Cul9, Parkin double KO mice. V.J and M.J.T. performed the stereological analysis and quantification of dopaminergic neurons. S.M. conducted and analysed the neurobehavioral assessments. M.D. outlined and supervised the project. E.H. and M.D. produced the final version of the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent6703377
dc.identifier219148913
dc.identifier8e1bb02c-d08c-41f7-84ff-f9fc424e2416
dc.identifier85092231984
dc.identifier33037272
dc.identifier000615371900019
dc.identifier.citationHollville, E, Joers, V, Nakamura, A, Swahari, V, Tansey, M G, Moy, S S & Deshmukh, M 2020, 'Characterization of a Cul9–Parkin double knockout mouse model for Parkinson’s disease', Scientific Reports, vol. 10, 16886. https://doi.org/10.1038/s41598-020-73854-yen
dc.identifier.doi10.1038/s41598-020-73854-y
dc.identifier.issn2045-2322
dc.identifier.otherORCID: /0000-0001-5711-8542/work/120621960
dc.identifier.urihttps://hdl.handle.net/2164/20249
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85092231984&partnerID=8YFLogxKen
dc.identifier.vol10en
dc.language.isoeng
dc.relation.ispartofScientific Reportsen
dc.subjectDiseases of the nervous systemen
dc.subjectNeuroscienceen
dc.subjectParkinson's diseaseen
dc.subjectR Medicineen
dc.subjectGeneralen
dc.subject.lccRen
dc.titleCharacterization of a Cul9–Parkin double knockout mouse model for Parkinson’s diseaseen
dc.typeJournal articleen

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