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A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models

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dc.contributor.authorMielnik, Catharine A
dc.contributor.authorSugamori, Kim S
dc.contributor.authorFinlay, David B
dc.contributor.authorThorpe, Hayley H A
dc.contributor.authorSchapira, Matthieu
dc.contributor.authorSivananthan, Nirunthan
dc.contributor.authorLi, Chun Kit
dc.contributor.authorlam, Vincent M
dc.contributor.authorHarrington, Sean
dc.contributor.authorAbdelrahman, Mostafa H
dc.contributor.authorTrembleau, Laurent A
dc.contributor.authorBurnham, W. McIntyre
dc.contributor.authorKhokhar, Jibran Y
dc.contributor.authorSalahpour, Ali
dc.contributor.authorRamsey, Amy J
dc.contributor.authorGlass, Michelle
dc.contributor.authorGreig, Iain R.
dc.contributor.authorRoss, Ruth A.
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2020-11-03T18:11:17Z
dc.date.available2020-11-03T18:11:17Z
dc.date.issued2021-01-31
dc.descriptionFunding and disclosure The authors declare the following financial and biomedical conflict of interests: Ruth A. Ross, Catharine A. Mielnik, Amy J. Ramsey, Iain R. Greig, Laurent A. Trembleau, Mostafa H. Abdelrahman are co-inventors on a patent application related to ABM300 and structural analogs. Kim S. Sugamori, David B. Finlay, Hayley H.A. Thorpe, Matthieu Schapira, Nirunthan Sivananthan, Chun Kit Li, Vincent M. Lam, Sean Harrington, W. McIntyre Burnham, Jibran Y. Khokhar, Ali Salahpour, Michelle Glass reported no biomedical financial interests or potential conflicts of interest. W. McIntyre Burnham received Δ9- (THC) as a gift from MedReleaf. The authors would like to gratefully acknowledge Wendy Horsfall for mouse colony maintenance. The work was funded by grants to RAR from CIHR (PPP-125784, PP2-139101), CIHR funding to AJR (MOP119298) and CIHR funding to AS (PJT-15619).en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent1335713
dc.format.extent2934890
dc.identifier173729592
dc.identifier785fe940-d67f-433c-a154-58e5f85fceee
dc.identifier33036015
dc.identifier33036015
dc.identifier000577958000001
dc.identifier85092394943
dc.identifier.citationMielnik, C A, Sugamori, K S, Finlay, D B, Thorpe, H H A, Schapira, M, Sivananthan, N, Li, C K, lam, V M, Harrington, S, Abdelrahman, M H, Trembleau, L A, Burnham, W M, Khokhar, J Y, Salahpour, A, Ramsey, A J, Glass, M, Greig, I R & Ross, R A 2021, 'A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models', Neuropsychopharmacology, vol. 46, no. 2, pp. 413-422. https://doi.org/10.1038/s41386-020-00876-5en
dc.identifier.doi10.1038/s41386-020-00876-5
dc.identifier.iss2en
dc.identifier.issn0893-133X
dc.identifier.otherORCID: /0000-0003-0603-3383/work/82958684
dc.identifier.otherORCID: /0000-0001-6376-9077/work/82959084
dc.identifier.urihttps://hdl.handle.net/2164/15313
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85092394943&partnerID=8YFLogxKen
dc.identifier.vol46en
dc.language.isoeng
dc.relation.ispartofNeuropsychopharmacologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectcannabinoiden
dc.subjectAllosteric modulatoren
dc.subjectpsychosisen
dc.subjecthyperdopaminergiaen
dc.subjectpharmacologyen
dc.subjectsensorimotor processingen
dc.subjectR Medicineen
dc.subjectPsychiatry and Mental healthen
dc.subjectPharmacologyen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleA novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent modelsen
dc.typeJournal articleen

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