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SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

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dc.contributor.authorNa, Juri
dc.contributor.authorNewman, Joseph A.
dc.contributor.authorThen, Chee Kin
dc.contributor.authorSyed, Junetha
dc.contributor.authorVendrell, Iolanda
dc.contributor.authorTorrecilla, Ignacio
dc.contributor.authorEllermann, Sophie
dc.contributor.authorRamadan, Kristijan
dc.contributor.authorFischer, Roman
dc.contributor.authorKiltie, Anne E.
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2021-06-15T21:16:01Z
dc.date.available2021-06-15T21:16:01Z
dc.date.issued2021-02-08
dc.descriptionFunding Information: This work was funded by CRUK Programme Grant C5255/A23755. Acknowledgements Mass spectrometry analysis was performed in the MS laboratory at the Target discovery institute—NDM (Oxford) led by Benedikt M. Kessler. We thank Drs. Eva McGrowder and Blaz Groselj for processing of primary bladder tumour samples to produce cell-free extracts. Data availability The LC-MS/MS proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE48 partner repository with the dataset identifier PXD017964 and 10.6019/PXD017964.en
dc.description.statusPeer revieweden
dc.format.extent17
dc.format.extent3308936
dc.identifier195022363
dc.identifier122a639c-a8ea-4678-94a8-b7981688de4b
dc.identifier85100630526
dc.identifier33558481
dc.identifier.citationNa, J, Newman, J A, Then, C K, Syed, J, Vendrell, I, Torrecilla, I, Ellermann, S, Ramadan, K, Fischer, R & Kiltie, A E 2021, 'SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells', Cell Death and Disease, vol. 12, no. 2, 165. https://doi.org/10.1038/s41419-021-03437-wen
dc.identifier.doi10.1038/s41419-021-03437-w
dc.identifier.iss2en
dc.identifier.issn2041-4889
dc.identifier.otherORCID: /0000-0001-7208-2912/work/96970513
dc.identifier.urihttps://hdl.handle.net/2164/16672
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85100630526&partnerID=8YFLogxKen
dc.identifier.vol12en
dc.language.isoeng
dc.relation.ispartofCell Death and Diseaseen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectImmunologyen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectCell Biologyen
dc.subjectCancer Researchen
dc.subjectCancer Research UKen
dc.subjectC5255/A23755en
dc.subjectSupplementary Dataen
dc.subjectSupplementary Informationen
dc.subjecthttps://doi.org/10.1038/s41419-021-03437-wen
dc.subject.lccRen
dc.titleSPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cellsen
dc.typeJournal articleen

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