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Synaptic Loss, ER Stress and Neuro-inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease

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dc.contributor.authorBuchanan, Heather
dc.contributor.authorMackay, Murray
dc.contributor.authorPalmer, Kerri
dc.contributor.authorTothová, Karolína
dc.contributor.authorKatsur, Miroslava
dc.contributor.authorPlatt, Bettina
dc.contributor.authorKoss, David J.
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2020-07-14T11:55:02Z
dc.date.available2020-07-14T11:55:02Z
dc.date.issued2020-08
dc.descriptionAcknowledgements We would like to deeply thank all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the Alzheimer’s Society and the Medical Research Council, and sourced from the MRC London Neurodegenerative Diseases Brain Bank, the Manchester Brain Bank, the South West Dementia Brain Bank (SWDBB), the Newcastle Brain Tissue Resource and the Oxford Brain Bank. The Newcastle Brain Tissue Resource and Oxford Brain Bank are also supported by the National Institute for Health Research (NIHR) Units. The South West Dementia Brain Bank (SWDBB) receives additional support from BRACE (Bristol Research into Alzheimer’s and Care of the Elderly). Use of human tissue for this work was approved by Brains for Dementia Research from London – City and East NRES committee 08/H0704/128+5. The work presented here was funded by Alzheimer’s Research UK (Grant refs: ARUK-PPG2014A-21, ARUK-NSG2015-1, ARUK-NCG2017A-3 awarded to DK and BP). HB was supported by an Alzheimer’s Society Doctoral Training Centre grant (grant ref: 228) to BP. MK’s participation in the project was funded by ARUK Scotland Network pump priming award to DK and BP. Antibodies CP13 and PHF1 were generously provided by Prof. Peter Davies. TOC1 antibodies were a gift from Nicholas Kanaan at Michigan State University (originally created by Lester Binder at Northwestern University). Funding The work presented here was funded by Alzheimer’s Research UK (Grant refs: ARUK-PPG2014A-21, ARUK-NSG2015-1, ARUK-NCG2017A-3 awarded to DK and BP). HB was supported by an Alzheimer’s Society Doctoral Training Centre grant (grant ref:228) to BP. MK’s participation in the project was funded by ARUK Scotland Network pump priming award to DK and BP.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent3454984
dc.identifier164149048
dc.identifier318cc380-705d-4ab9-91a7-f4a2c5459bc1
dc.identifier000538975700003
dc.identifier32514860
dc.identifier85086107840
dc.identifier.citationBuchanan, H, Mackay, M, Palmer, K, Tothová, K, Katsur, M, Platt, B & Koss, D J 2020, 'Synaptic Loss, ER Stress and Neuro-inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease', Molecular Neurobiology, vol. 57, pp. 3258-3272. https://doi.org/10.1007/s12035-020-01950-1en
dc.identifier.doi10.1007/s12035-020-01950-1
dc.identifier.issn0893-7648
dc.identifier.otherSCOPUS: 85086107840
dc.identifier.otherORCID: /0000-0002-7852-0749/work/76976857
dc.identifier.urihttps://hdl.handle.net/2164/14702
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85086107840&partnerID=8YFLogxKen
dc.identifier.urlhttps://rdcu.be/b4Khuen
dc.identifier.vol57en
dc.language.isoeng
dc.relation.ispartofMolecular Neurobiologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAlzheimer's diseaseen
dc.subjecttauen
dc.subjectamyloiden
dc.subjectSynapseen
dc.subjectunfolded protein responseen
dc.subjectneuroinflammationen
dc.subjectNeuro-inflammationen
dc.subjectHUMAN BRAINen
dc.subjectPHOSPHORYLATIONen
dc.subjectTRANSGENIC MOUSEen
dc.subjectTauen
dc.subjectAMYLOID-BETA-PROTEINen
dc.subjectENDOPLASMIC-RETICULUM STRESSen
dc.subjectMODELen
dc.subjectUnfolded protein responseen
dc.subjectCOGNITIVE DECLINEen
dc.subjectUNFOLDED PROTEIN RESPONSEen
dc.subjectEIF2-ALPHAen
dc.subjectEXPRESSIONen
dc.subjectAmyloid-betaen
dc.subjectAlzheimer’s diseaseen
dc.subjectAmyloid-βen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNeurologyen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectAlzheimers Research UKen
dc.subjectARUK-PPG2014A-21en
dc.subjectARUK-NSG2015-1en
dc.subjectARUK-NCG2017A-3en
dc.subjectSupplementary Dataen
dc.subject.lccRC0321en
dc.titleSynaptic Loss, ER Stress and Neuro-inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Diseaseen
dc.typeJournal articleen

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