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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies novel loci associated with serum lipids

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dc.contributor.authorBentley, Amy R
dc.contributor.authorSung, Yun J
dc.contributor.authorBrown, Michael R
dc.contributor.authorWinkler, Thomas W
dc.contributor.authorKraja, Aldi T
dc.contributor.authorNtalla, Ioanna
dc.contributor.authorSchwander, Karen
dc.contributor.authorChasman, Daniel I
dc.contributor.authorLim, Elise
dc.contributor.authorDeng, Xuan
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorLiu, Jingmin
dc.contributor.authorLu, Yingchang
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorSim, Xueling
dc.contributor.authorVojinovic, Dina
dc.contributor.authorHuffman, Jennifer E
dc.contributor.authorMusani, Solomon K
dc.contributor.authorLi, Changwei
dc.contributor.authorFeitosa, Mary F
dc.contributor.authorRichard, Melissa A
dc.contributor.authorNoordam, Raymond
dc.contributor.authorBaker, Jenna
dc.contributor.authorChen, Guanjie
dc.contributor.authorAschard, Hugues
dc.contributor.authorBartz, Traci M
dc.contributor.authorDing, Jingzhong
dc.contributor.authorDorajoo, Rajkumar
dc.contributor.authorManning, Alisa K
dc.contributor.authorRankinen, Tuomo
dc.contributor.authorSmith, Albert V
dc.contributor.authorTajuddin, Salman M
dc.contributor.authorZhao, Wei
dc.contributor.authorGraff, Mariaelisa
dc.contributor.authorAlver, Maris
dc.contributor.authorBoissel, Mathilde
dc.contributor.authorChai, Jin Fang
dc.contributor.authorChen, Xu
dc.contributor.authorDivers, Jasmin
dc.contributor.authorEvangelou, Evangelos
dc.contributor.authorGao, Chuan
dc.contributor.authorGoel, Anuj
dc.contributor.authorHagemeijer, Yanick
dc.contributor.authorHarris, Sarah E
dc.contributor.authorHartwig, Fernando P
dc.contributor.authorHe, Meian
dc.contributor.authorHorimoto, Andrea R V R
dc.contributor.authorHsu, Fang-Chi
dc.contributor.authorHung, Yi-Jen
dc.contributor.authorMurray, Alison D
dc.contributor.authorCOGENT-Kidney Consortium
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2019-09-28T23:04:06Z
dc.date.available2019-09-28T23:04:06Z
dc.date.issued2019-04
dc.descriptionThis project was largely supported by a grant from the US National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (R01HL118305) and by the Intramural Research Program of the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (Z01HG200362). Anne E Justice was supported in part by the American Heart Association (13POST16500011) and NIH (2T32HL007055, K99HL130580). Study-specific acknowledgments appear in the Supplementary Information. All summary results will be made available in dbGaP (phs000930.v7.p1).en
dc.description.statusPeer revieweden
dc.format.extent13
dc.format.extent1459257
dc.identifier141472334
dc.identifier3f43340b-a3b5-43bd-b652-d16d16527c46
dc.identifier30926973
dc.identifier30926973
dc.identifier85063914316
dc.identifier000462767500011
dc.identifier.citationBentley, A R, Sung, Y J, Brown, M R, Winkler, T W, Kraja, A T, Ntalla, I, Schwander, K, Chasman, D I, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Huffman, J E, Musani, S K, Li, C, Feitosa, M F, Richard, M A, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, T M, Ding, J, Dorajoo, R, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, Hartwig, F P, He, M, Horimoto, A R V R, Hsu, F-C, Hung, Y-J, Murray, A D & COGENT-Kidney Consortium 2019, 'Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies novel loci associated with serum lipids', Nature Genetics, vol. 51, no. 4, pp. 636-648. https://doi.org/10.1038/s41588-019-0378-yen
dc.identifier.doi10.1038/s41588-019-0378-y
dc.identifier.iss4en
dc.identifier.issn1061-4036
dc.identifier.otherMendeley: 5506b1c4-100e-38ba-9c8a-538493665cc6
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976581
dc.identifier.urihttp://hdl.handle.net/2164/13021
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85063914316&partnerID=8YFLogxKen
dc.identifier.urlhttp://www.mendeley.com/research/multiancestry-genomewide-genesmoking-interaction-study-387272-individuals-identifies-new-loci-associen
dc.identifier.urlhttps://rdcu.be/buCgcen
dc.identifier.vol51en
dc.language.isoeng
dc.relation.ispartofNature Geneticsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectcardiovascular diseasesen
dc.subjectgenome wide association studiesen
dc.subjectgenomicsen
dc.subjectENVIRONMENT INTERACTIONen
dc.subjectMETAANALYSISen
dc.subjectCHOLESTEROLen
dc.subjectCIGARETTESen
dc.subjectVARIANTSen
dc.subjectSUSCEPTIBILITYen
dc.subjectNICOTINE METABOLISMen
dc.subjectRISK LOCIen
dc.subjectGENOTYPE IMPUTATIONen
dc.subjectARCHITECTUREen
dc.subjectQH426 Geneticsen
dc.subjectGeneticsen
dc.subjectSupplementary Dataen
dc.subject.lccQH426en
dc.titleMulti-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies novel loci associated with serum lipidsen
dc.typeJournal articleen

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