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Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network

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dc.contributor.authorMagloire, Vincent
dc.contributor.authorSavtchenko, Leonid P.
dc.contributor.authorJensen, Thomas P.
dc.contributor.authorSylantyev, Sergyi
dc.contributor.authorKopach, Olga
dc.contributor.authorCole, Nicholas
dc.contributor.authorTyurikova, Olga
dc.contributor.authorKullmann, Dimitri M.
dc.contributor.authorWalker, Matthew C.
dc.contributor.authorMarvin, Jonathan S.
dc.contributor.authorLooger, Loren L.
dc.contributor.authorHasseman, Jeremy P.
dc.contributor.authorKolb, Ilya
dc.contributor.authorPavlov, Ivan
dc.contributor.authorRusakov, Dmitri A.
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2023-05-03T10:59:01Z
dc.date.available2023-05-03T10:59:01Z
dc.date.issued2023-04-10
dc.descriptionFunding Information: This work was supported by Wellcome Principal Fellowship (212251/Z/18/Z and 212285/Z/18/Z), Wellcome Collaborative Award (UNS120639 - 223131/Z/21/Z), Epilepsy Research UK (F1901), MRC (MR/W019752/1, MR/V013556/1, and MR/V034758/1), NC3Rs (NC/X001067/1), and ERC Advanced Grant (323113). Optimization and parallelization of ARACHNE algorithms for extended neural network simulations was provided by AMC Bridge (Waltham, MA) and web security by Cyber Curio (Berkhamsted, UK). L.P.S. and D.A.R. narrated the study. I.P. and V.M. designed and carried out electrophysiological and optogenetic studies. N.C. O.K. and T.P.J. designed, carried out, and analyzed iGABASnFR2 imaging experiments. S.S. carried out sniffer-patch experiments. O.T. carried out control-probing K+ imaging tests. L.P.S. designed and carried out network modeling studies and data analyses. J.S.M. L.L.L. J.P.H. and I.K. supplied optical GABA sensors and related protocols. The development of iGABASnFR2 was conducted under the aegis of the HHMI Janelia GENIE Project at Janelia Research Campus. D.M.K. and M.C.W. designed optogenetic experiments. D.A.R. designed selected experiments and simulations, carried out selected analyses, and wrote the manuscript draft, with contributions from V.M. L.P.S. and all other authors. The authors declare no competing interests. We support inclusive, diverse, and equitable conduct of research. Publisher Copyright: © 2023 The Author(s)en
dc.description.statusPeer revieweden
dc.format.extent13554790
dc.identifier241747078
dc.identifier8ed6c487-e829-43a6-9e5f-ddfdaf1ebada
dc.identifier85151495947
dc.identifier36921605
dc.identifier.citationMagloire, V, Savtchenko, L P, Jensen, T P, Sylantyev, S, Kopach, O, Cole, N, Tyurikova, O, Kullmann, D M, Walker, M C, Marvin, J S, Looger, L L, Hasseman, J P, Kolb, I, Pavlov, I & Rusakov, D A 2023, 'Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network', Current Biology, vol. 33, no. 7, pp. 1249-1264.e7. https://doi.org/10.1016/j.cub.2023.02.051en
dc.identifier.doi10.1016/j.cub.2023.02.051
dc.identifier.iss7en
dc.identifier.issn0960-9822
dc.identifier.otherORCID: /0000-0002-1358-0601/work/134240338
dc.identifier.urihttps://hdl.handle.net/2164/20621
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85151495947&partnerID=8YFLogxKen
dc.identifier.vol33en
dc.language.isoeng
dc.relation.ispartofCurrent Biologyen
dc.subjectbrain rhythmsen
dc.subjectepilepsyen
dc.subjectextracellular GABAen
dc.subjectGABA uptakeen
dc.subjectGAT-1en
dc.subjectiGABASnFR2en
dc.subjectspiking neural networksen
dc.subjecttonic GABA conductanceen
dc.subjectvolume transmissionen
dc.subjectR Medicineen
dc.subjectGeneral Neuroscienceen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectGeneral Agricultural and Biological Sciencesen
dc.subjectWellcome Trusten
dc.subject212251/Z/18/Zen
dc.subject212285/Z/18/Zen
dc.subjectUNS120639 - 223131/Z/21/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/W019752/1en
dc.subjectMR/V013556/1en
dc.subjectMR/V034758/1en
dc.subjectNational Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3R's)en
dc.subjectNC/X001067/1en
dc.subjectEuropean Research Councilen
dc.subject323113en
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleVolume-transmitted GABA waves pace epileptiform rhythms in the hippocampal networken
dc.typeJournal articleen

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