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C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

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dc.contributor.authorSelvaraj, Bhuvaneish T.
dc.contributor.authorLivesey, Matthew R.
dc.contributor.authorZhao, Chen
dc.contributor.authorGregory, Jenna M.
dc.contributor.authorJames, Owain T.
dc.contributor.authorCleary, Elaine M.
dc.contributor.authorChouhan, Amit K.
dc.contributor.authorGane, Angus B.
dc.contributor.authorPerkins, Emma M.
dc.contributor.authorDando, Owen
dc.contributor.authorLillico, Simon G.
dc.contributor.authorLee, Youn Bok
dc.contributor.authorNishimura, Agnes L.
dc.contributor.authorPoreci, Urjana
dc.contributor.authorThankamony, Sai
dc.contributor.authorPray, Meryll
dc.contributor.authorVasistha, Navneet A.
dc.contributor.authorMagnani, Dario
dc.contributor.authorBorooah, Shyamanga
dc.contributor.authorBurr, Karen
dc.contributor.authorStory, David
dc.contributor.authorMcCampbell, Alexander
dc.contributor.authorShaw, Christopher E.
dc.contributor.authorKind, Peter C.
dc.contributor.authorAitman, Timothy J.
dc.contributor.authorWhitelaw, C. Bruce A.
dc.contributor.authorWilmut, Ian
dc.contributor.authorSmith, Colin
dc.contributor.authorMiles, Gareth B.
dc.contributor.authorHardingham, Giles E.
dc.contributor.authorWyllie, David J.A.
dc.contributor.authorChandran, Siddharthan
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2024-03-13T13:06:01Z
dc.date.available2024-03-13T13:06:01Z
dc.date.issued2018-01-24
dc.descriptionFunded by The Wellcome Trust (Grant 092742/Z/10/Z), MNDA (Miles/Oct14/878-792), MRC, Euan MacDonald Centre, UK DRI, DBT-India, ISSF (WT/UoE), Royal Society of Edinburgh (CRF), and Biogen/UoE Joint Discovery Research Collaboration. RNA-Seqraw reads were generated by Edinburgh Genomics, The University of Edinburgh. Edinburgh Genomics is partly supported through core grants from NERC (R8/H10/56), MRC (MR/K001744/1), and BBSRC (BB/J004243/1).en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent5567836
dc.identifier217897658
dc.identifiere6cf6d0b-2c75-42c1-bf59-65624545d7d8
dc.identifier85041044335
dc.identifier29367641
dc.identifier.citationSelvaraj, B T, Livesey, M R, Zhao, C, Gregory, J M, James, O T, Cleary, E M, Chouhan, A K, Gane, A B, Perkins, E M, Dando, O, Lillico, S G, Lee, Y B, Nishimura, A L, Poreci, U, Thankamony, S, Pray, M, Vasistha, N A, Magnani, D, Borooah, S, Burr, K, Story, D, McCampbell, A, Shaw, C E, Kind, P C, Aitman, T J, Whitelaw, C B A, Wilmut, I, Smith, C, Miles, G B, Hardingham, G E, Wyllie, D J A & Chandran, S 2018, 'C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca 2+ -permeable AMPA receptor-mediated excitotoxicity', Nature Communications, vol. 9, 347. https://doi.org/10.1038/s41467-017-02729-0en
dc.identifier.doi10.1038/s41467-017-02729-0
dc.identifier.issn2041-1723
dc.identifier.otherORCID: /0000-0003-3337-4079/work/115465459
dc.identifier.urihttps://hdl.handle.net/2164/22999
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85041044335&partnerID=8YFLogxKen
dc.identifier.vol9en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectQ Scienceen
dc.subjectGeneral Chemistryen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectGeneral Physics and Astronomyen
dc.subjectWellcome Trusten
dc.subject092742/Z/10/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K001744/1en
dc.subjectNatural Environment Research Council (NERC)en
dc.subjectR8/H10/56en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/J004243/1en
dc.subjectSupplementary Informationen
dc.subject.lccQen
dc.titleC9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicityen
dc.typeJournal articleen

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