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An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly

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dc.contributor.authorPhilippe, Lucas
dc.contributor.authorPandarakalam, George C.
dc.contributor.authorFasimoye, Rotimi
dc.contributor.authorHarrison, Neale
dc.contributor.authorConnolly, Bernadette
dc.contributor.authorPettitt, Jonathan
dc.contributor.authorMuller, Berndt
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2017-06-05T12:00:26Z
dc.date.available2017-06-05T12:00:26Z
dc.date.issued2017-08-21
dc.descriptionACKNOWLEDGEMENTS Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). We would also like to thank Prof. Shohei Mitani,at the National Bioresource Project for the Experimental Animal ‘Nematode C. elegans’, Japan, for FX3079. We are grateful to Prof. Tom Blumenthal (University of Colorado, Boulder) for suggestions and support of this work; and to Kathrine Wood for her contribution to the initial stages of part of this work. Author contributions. L.P., G.P., R.F., N.H., J.P. and B.M. performed experiments; B.M., J.P. and B.C. designed and lead the study; B.M. and J.P. drafted the manuscript. All authors reviewed the manuscript. FUNDING Biotechnology and Biological Sciences Research Council (BBSRC) [Project grant BB/J007137/1]; Medical Research Council (MRC) Confidence in Concept 2014 - University of Aberdeen Award(MC PC 14114v.2); University of Aberdeen Elphinstone Scholarship (to R.F.) and TET Fund support through Adekunle Ajasin University, Nigeria (to R.F.). Funding for open access charge: Biotechnology and Biological Sciences Research Council and Medical Research Council.en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent4260830
dc.identifier101153943
dc.identifier5c833370-19ee-4f43-a89f-287b19833814
dc.identifier85031849724
dc.identifier.citationPhilippe, L, Pandarakalam, G C, Fasimoye, R, Harrison, N, Connolly, B, Pettitt, J & Muller, B 2017, 'An in vivo genetic screen for genes involved in spliced leader trans -splicing indicates a crucial role for continuous de novo spliced leader RNP assembly', Nucleic Acids Research, vol. 45, no. 14, pp. 8474-8483. https://doi.org/10.1093/nar/gkx500, https://doi.org/10.1093/nar/gkx500en
dc.identifier.doi10.1093/nar/gkx500
dc.identifier.iss14en
dc.identifier.issn0305-1048
dc.identifier.otherORCID: /0000-0003-1279-5421/work/60546392
dc.identifier.otherORCID: /0000-0001-8195-7880/work/57461220
dc.identifier.otherORCID: /0000-0001-7988-6833/work/160389558
dc.identifier.otherORCID: /0000-0003-1279-5421/work/60546392
dc.identifier.urihttp://hdl.handle.net/2164/8751
dc.identifier.urlhttps://abdn.elsevierpure.com/en/publications/5c833370-19ee-4f43-a89f-287b19833814en
dc.identifier.vol45en
dc.language.isoeng
dc.relation.ispartofNucleic Acids Researchen
dc.subjectgenesen
dc.subjectrna splicingen
dc.subjectgeneticsen
dc.subjectrnaen
dc.subjectR Medicineen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/J007137/1en
dc.subjectMedical Research Council (MRC)en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleAn in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assemblyen
dc.typeJournal articleen

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