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Microvasculopathy in SMA is driven by a reversible autonomous endothelial cell defect

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dc.contributor.authorZhou, Haiyan
dc.contributor.authorHong, Ying
dc.contributor.authorScoto, Mariacristina
dc.contributor.authorThomson, Alison
dc.contributor.authorPead, Emma
dc.contributor.authorMacGillivray, Tom
dc.contributor.authorHernandez Gerez, Elena
dc.contributor.authorCatapano, Francesco
dc.contributor.authorMeng, Jinhong
dc.contributor.authorZhang, Qiang
dc.contributor.authorHunter, Gillian
dc.contributor.authorShorrock, Hannah K.
dc.contributor.authorNg, Thomas
dc.contributor.authorHamida, Abedallah Mahmod Shehda
dc.contributor.authorSanson, Mathilde
dc.contributor.authorBaranello, Giovanni
dc.contributor.authorHowell, Kevin
dc.contributor.authorGillingwater, Thomas H.
dc.contributor.authorBrogan, Paul
dc.contributor.authorThompson, Dorothy
dc.contributor.authorParson, Simon
dc.contributor.authorMuntoni, Francesco
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.The Suttie Centre - Anatomyen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2023-07-06T15:52:00Z
dc.date.available2023-07-06T15:52:00Z
dc.date.issued2022-11-01
dc.descriptionAcknowledgments We would like to thank Professor Peter Carmeliet at University of Leuven for help with initial mouse retina dissection and staining, Prof Martin Collinson at University of Aberdeen for assistance in staining cells in mouse retinas and Professor Jennifer E. Morgan at University College London for overseeing experiments in mice. This study was supported in part by research funding from the Great Ormond Street Hospital Charity to FM and PB (Reference V0216), Wellcome Trust grant to HZ (Reference 204841/Z/16/Z), UK SMA Trust to FM and MS, SMA Europe grants to FM, THG and SHP, and Anatomical Society PhD Studentship to SHP. Financial support from the National Institute for Health Research (NIHR) Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London to FM and HZ is acknowledged. The views expressed are those of the authors and not necessarily those of the UK National Health Service (NHS), the NIHR, or the Department of Health. The supports of the MRC Neuromuscular Centre at UCL and of the Muscular Dystrophy UK to the Dubowitz Neuromuscular Centre are also acknowledged.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent7449972
dc.identifier218832124
dc.identifier9855dce9-81da-4227-8d65-6cfdf27948ef
dc.identifier36099045
dc.identifier85141004368
dc.identifier.citationZhou, H, Hong, Y, Scoto, M, Thomson, A, Pead, E, MacGillivray, T, Hernandez Gerez, E, Catapano, F, Meng, J, Zhang, Q, Hunter, G, Shorrock, H K, Ng, T, Hamida, A M S, Sanson, M, Baranello, G, Howell, K, Gillingwater, T H, Brogan, P, Thompson, D, Parson, S & Muntoni, F 2022, 'Microvasculopathy in SMA is driven by a reversible autonomous endothelial cell defect', Journal of Clinical Investigation, vol. 132, no. 21, e153430. https://doi.org/10.1172/JCI153430en
dc.identifier.doi10.1172/JCI153430
dc.identifier.iss21en
dc.identifier.issn0021-9738
dc.identifier.otherORCID: /0000-0002-8848-8738/work/119826080
dc.identifier.otherORCID: /0000-0002-2373-0423/work/121963961
dc.identifier.urihttps://hdl.handle.net/2164/21135
dc.identifier.vol132en
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Investigationen
dc.subjectSubstantive connection via an eligible employment contracten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subject204841/Z/16/Zen
dc.subjectOtheren
dc.subjectV0216en
dc.subjectEuropean Commissionen
dc.subjectH2020-MSCA-ITN-2020en
dc.subject956185en
dc.subjectSMABEYONDen
dc.subject.lccRen
dc.titleMicrovasculopathy in SMA is driven by a reversible autonomous endothelial cell defecten
dc.typeJournal articleen

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