University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants

Simple item page
dc.contributor.authorNagy, Reka
dc.contributor.authorBoutin, Thibaud S
dc.contributor.authorMarten, Jonathan
dc.contributor.authorHuffman, Jennifer E
dc.contributor.authorKerr, Shona M
dc.contributor.authorCampbell, Archie
dc.contributor.authorEvenden, Louise
dc.contributor.authorGibson, Jude
dc.contributor.authorAmador, Carmen
dc.contributor.authorHoward, David M
dc.contributor.authorNavarro, Pau
dc.contributor.authorMorris, Andrew
dc.contributor.authorDeary, Ian J
dc.contributor.authorHocking, Lynne J
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorSmith, Blair H
dc.contributor.authorJoshi, Peter
dc.contributor.authorWilson, James F
dc.contributor.authorHastie, Nicholas D
dc.contributor.authorWright, Alan F
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorPorteous, David J
dc.contributor.authorHaley, Chris S
dc.contributor.authorVitart, Veronique
dc.contributor.authorHayward, Caroline
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.date.accessioned2017-08-30T09:00:13Z
dc.date.available2017-08-30T09:00:13Z
dc.date.issued2017-03-07
dc.descriptionAcknowledgements We are grateful to all the families who took part in the Generation Scotland: Scottish Family Health Study, the general practitioners and Scottish School of Primary Care for their help in recruiting them, and the whole Generation Scotland team, which includes academic researchers, IT staff, laboratory technicians, statisticians and research managers. We thank staff at the University of Dundee Health Informatics Centre for their expert assistance with EHR data linkage. IJD is supported by The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1); funding from the BBSRC and MRC is gratefully acknowledged. Data on glycaemic traits have been contributed by MAGIC investigators and have been downloaded from www.magicinvestigators.org. Funding Genotyping of the GS:SFHS samples was carried out by the Edinburgh Clinical Research Facility, University of Edinburgh and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award ‘STratifying Resilience and Depression Longitudinally’ (STRADL) (Reference 104036/Z/14/Z). GS:SFHS received core support from the Scottish Executive Health Department, Chief Scientist Office, grant number CZD/16/6. The MRC provides core funding to the QTL in Health and Disease research program at the MRC HGU, IGMM, University of Edinburgh. Availability of data and materials The datasets supporting the conclusions of this article are included within the article (and its Additional files). https://figshare.com/collections/Exploration_of_haplotype_research_consortium_imputation_for_genome-wide_association_studies_in_20_032_Generation_Scotland_participants/3711706en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent1050299
dc.identifier107333824
dc.identifier336abc4d-d43a-430c-b0c9-1be9dd4da80f
dc.identifier28270201
dc.identifier85014693893
dc.identifier.citationNagy, R, Boutin, T S, Marten, J, Huffman, J E, Kerr, S M, Campbell, A, Evenden, L, Gibson, J, Amador, C, Howard, D M, Navarro, P, Morris, A, Deary, I J, Hocking, L J, Padmanabhan, S, Smith, B H, Joshi, P, Wilson, J F, Hastie, N D, Wright, A F, McIntosh, A M, Porteous, D J, Haley, C S, Vitart, V & Hayward, C 2017, 'Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants', Genome Research, vol. 9, 23, pp. 1-14. https://doi.org/10.1186/s13073-017-0414-4en
dc.identifier.doi10.1186/s13073-017-0414-4
dc.identifier.issn1088-9051
dc.identifier.otherPubMedCentral: PMC5339960
dc.identifier.urihttp://hdl.handle.net/2164/9226
dc.identifier.vol9en
dc.language.isoeng
dc.relation.ispartofGenome Researchen
dc.subjectGenome-wide association studies (GWAS)en
dc.subjectElectronic health recordsen
dc.subjectImputationen
dc.subjectQuantitative traiten
dc.subjectGeneticsen
dc.subjectUrateen
dc.subjectHeart rateen
dc.subjectGlucoseen
dc.subjectHaplotype Research Consortium (HRC)en
dc.subjectQH426 Geneticsen
dc.subjectMedical Research Council (MRC)en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subject.lccQH426en
dc.titleExploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participantsen
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
s13073_017_0414_4.pdf
Size:
1 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
8.31 KB
Format:
Plain Text
Description:
Download

Collections

All research
Applied Medicine research
University Office research