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Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability

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dc.contributor.authorMitchell, Joanne L.
dc.contributor.authorLittle, Gemma
dc.contributor.authorBye, Alexander P.
dc.contributor.authorGaspar, Renato S.
dc.contributor.authorUnsworth, Amanda J.
dc.contributor.authorKriek, Neline
dc.contributor.authorSage, Tanya
dc.contributor.authorStainer, Alexander
dc.contributor.authorSangowawa, Ibidayo
dc.contributor.authorMorrow, Gael B.
dc.contributor.authorBastos, Ricardo N.
dc.contributor.authorShapiro, Susan
dc.contributor.authorDesborough, Michael J.R.
dc.contributor.authorCurry, Nicola
dc.contributor.authorGibbins, Jonathan M.
dc.contributor.authorWhyte, Claire S.
dc.contributor.authorMutch, Nicola J.
dc.contributor.authorJones, Christopher I.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2023-08-18T13:54:01Z
dc.date.available2023-08-18T13:54:01Z
dc.date.issued2023-07
dc.descriptionFunding Information: The authors thank Dr Ana Raquel Pereira from Oxford Nanoimaging for help with the direct STORM imaging and analysis. The authors also thank the microscopy core facilities at the University of Reading and the University of Aberdeen for excellent advice and use of the microscopes and facilities. The authors further thank Christopher Deane from the Oxford Haemophilia and Thrombosis centre for assistance with patient blood collection and Dr Nicholas Michael from the University of Reading Mass Spectrometry facility for performing mass spectrometry. This study was supported by the University of Reading School of Biological Sciences Seed funding grant (J.L.M.) and a grant from the British Heart Foundation (PG/16/36/31967, to C.I.J. and J.M.G.) and by the University of Aberdeen Development Trust (N.J.M. and J.L.M.). S.S. receives funding support from the Medical Research Council (MR/T024054/1). Informed consent was given by all normal health blood donors on this study with ethical approval from the University of Reading Research Ethics Committee (UREC 20/20). Informed consent was given by all patients recruited in this study with ethical approval by the Oxford Biobank (ORB Research Tissue Bank (RTB) ethics approval 09/H0606/5+5). J.L.M. conceptualized and designed the research, performed experiments, analyzed and interpreted data, and wrote the manuscript. G.L. performed the experiments and analyzed data. A.P.B. performed experiments and analyzed the data. R.S.G. performed experiments and analyzed data. A.J.U. performed experiments, analyzed data, and wrote the manuscript. N.K. performed experiments and analyzed data. T.S. performed experiments. A.S. performed experiments and analyzed data. I.S. performed experiments and analyzed data. G.B.M. performed experiments and analyzed data. R.N.B. performed experiments and analyzed data. S.S. provided patient samples and clinical advice. N.C. provided patient samples and clinical advice. J.M.G. interpreted data, obtained ethical approval for controls, and wrote the manuscript. C.S.W. interpreted data and wrote the manuscript. M.J.R.D. provided patient samples, obtained patient ethical approval, and provided clinical advice. N.J.M. designed the research, interpreted data, and wrote the manuscript. C.I.J. designed the research, interpreted data, obtained patient ethical approval, and wrote the manuscript. R.N.B is Director of Business Development at Oxford Nanoimaging.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent5239586
dc.identifier272903193
dc.identifier77568b10-e3dd-4088-bd68-f60ee3f2ab84
dc.identifier85166003061
dc.identifier37601014
dc.identifier.citationMitchell, J L, Little, G, Bye, A P, Gaspar, R S, Unsworth, A J, Kriek, N, Sage, T, Stainer, A, Sangowawa, I, Morrow, G B, Bastos, R N, Shapiro, S, Desborough, M J R, Curry, N, Gibbins, J M, Whyte, C S, Mutch, N J & Jones, C I 2023, 'Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability', Research and Practice in Thrombosis and Haemostasis, vol. 7, no. 5, 100200. https://doi.org/10.1016/j.rpth.2023.100200en
dc.identifier.doi10.1016/j.rpth.2023.100200
dc.identifier.otherORCID: /0000-0001-9299-6754/work/140898542
dc.identifier.otherORCID: /0000-0001-8127-6102/work/140899326
dc.identifier.otherORCID: /0000-0002-7452-0813/work/169538879
dc.identifier.urihttps://hdl.handle.net/2164/21498
dc.identifier.urlhttps://www.scopus.com/pages/publications/85166003061en
dc.language.isoeng
dc.relation.ispartofResearch and Practice in Thrombosis and Haemostasisen
dc.subjectclot retractionen
dc.subjectfactor XIIIen
dc.subjectfibrinogenen
dc.subjectfibrinolysisen
dc.subjectplateleten
dc.subjectplatelet activationen
dc.subjectR Medicineen
dc.subjectHematologyen
dc.subject.lccRen
dc.titlePlatelet factor XIII-A regulates platelet function and promotes clot retraction and stabilityen
dc.typeJournal articleen

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