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Colorectal tumors require NUAK1 for protection from oxidative stress

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dc.contributor.authorPort, Jennifer L. F.
dc.contributor.authorMuthalagu, Nathiya
dc.contributor.authorRaja, Meera
dc.contributor.authorCeteci, Fatih
dc.contributor.authorMonteverde, Tiziana
dc.contributor.authorKruspig, Bjorn
dc.contributor.authorHedley, Ann
dc.contributor.authorKalna, Gabriela
dc.contributor.authorLilla, Sergio
dc.contributor.authorNeilson, Lisa
dc.contributor.authorBrucoli, Martina
dc.contributor.authorGyuraszova, Katarina
dc.contributor.authorTait-Mulder, Jacqueline
dc.contributor.authorMezna, Mokdad
dc.contributor.authorSvambaryte, Silvija
dc.contributor.authorBryson, Amy
dc.contributor.authorSumpton, David
dc.contributor.authorMcVie, Allan
dc.contributor.authorNixon, Colin
dc.contributor.authorDrysdale, Martin
dc.contributor.authorEsumi, Hiroyasu
dc.contributor.authorMurray, Graeme I.
dc.contributor.authorSansom, Owen J.
dc.contributor.authorZanivan, Sara
dc.contributor.authorMurphy, Daniel J.
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2019-03-02T00:02:57Z
dc.date.available2019-03-02T00:02:57Z
dc.date.embargoedUntil2019-03-02
dc.date.issued2018-05
dc.descriptionThe authors wish to thank the staff of the CRUK Beatson Institute Biological Services Unit for animal husbandry and assistance with in vivo experiments; the staff of the CRUK BI Histology core facility and William Clark of the NGS core facility; David McGarry, Rene Jackstadt, Jiska Van der Reest, Justin Bower and Heather McKinnon for many helpful discussions, and countless colleagues at the CRUK BI and Glasgow Institute of Cancer Sciences for support; Prem Premsrirut & Mirimus Inc. for design and generation of dox-inducible Nuak1 shRNA expressing mice Nathanael Gray for initial provision of NUAK1 inhibitors. Funding was provided by the University of Glasgow and the CRUK Beaton Institute. J.P. was supported by European Commission Marie Curie actions C.I.G. 618448 “SERPLUC” to D.J.M.; N.M. was supported through Worldwide Cancer (formerly AICR) grant 15-0279 to O.J.S. & D.J.M.; B.K. was funded through EC Marie Curie actions mobility award 705190 “NuSiCC”; T.M. was funded through British Lung Foundation grant APHD13-5. The laboratories of S.R.Z. (A12935), O.J.S. (A21139) and M.D. (A17096) are funded by Cancer Research UK. O.J.S. was additionally supported by European Research Council grant 311301 “ColoCan”.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent983279
dc.identifier116904788
dc.identifier1b9f29b7-62b8-4ddb-a507-c2dea56899e3
dc.identifier85047882254
dc.identifier.citationPort, J L F, Muthalagu, N, Raja, M, Ceteci, F, Monteverde, T, Kruspig, B, Hedley, A, Kalna, G, Lilla, S, Neilson, L, Brucoli, M, Gyuraszova, K, Tait-Mulder, J, Mezna, M, Svambaryte, S, Bryson, A, Sumpton, D, McVie, A, Nixon, C, Drysdale, M, Esumi, H, Murray, G I, Sansom, O J, Zanivan, S & Murphy, D J 2018, 'Colorectal tumors require NUAK1 for protection from oxidative stress', Cancer Discovery, vol. 8, no. 5, pp. 633-647. https://doi.org/10.1158/2159-8290.CD-17-0533en
dc.identifier.doi10.1158/2159-8290.CD-17-0533
dc.identifier.iss5en
dc.identifier.issn2159-8274
dc.identifier.otherBibtex: urn:1f0a9aa21c42a363cc7e8e409ffaf0a5
dc.identifier.otherORCID: /0000-0003-3981-2420/work/76973503
dc.identifier.urihttp://hdl.handle.net/2164/11988
dc.identifier.vol8en
dc.language.isoeng
dc.relation.ispartofCancer Discoveryen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectNUAK1en
dc.subjectARK5en
dc.subjectNRF2en
dc.subjectoxidative stressen
dc.subjectcolorectal canceren
dc.subjectcancer therapyen
dc.subjectR Medicineen
dc.subject.lccRen
dc.titleColorectal tumors require NUAK1 for protection from oxidative stressen
dc.typeJournal articleen

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