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In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

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dc.contributor.authorRoss, Zoe K.
dc.contributor.authorAlsayegh, Sakinah
dc.contributor.authorZhao, Yixin
dc.contributor.authorMcPherson, Steven
dc.contributor.authorMunro, Carol A.
dc.contributor.authorLorenz, Alexander
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Microbiology and Immunityen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Molecular and Cellular Functionen
dc.date.accessioned2025-12-10T15:37:01Z
dc.date.issued2025-12
dc.descriptionOpen Access via the Elsevier agreementen
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent5072401
dc.identifier308087187
dc.identifierb4c52d19-d427-435a-9c7a-4c4c2485d99f
dc.identifier105013742082
dc.identifier40845729
dc.identifier.citationRoss, Z K, Alsayegh, S, Zhao, Y, McPherson, S, Munro, C A & Lorenz, A 2025, 'In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence', Microbiological Research, vol. 301, 128322. https://doi.org/10.1016/j.micres.2025.128322en
dc.identifier.doi10.1016/j.micres.2025.128322
dc.identifier.issn0944-5013
dc.identifier.otherRIS: urn:2D239CE725DE932BD6E3B0D76356DC5F
dc.identifier.otherORCID: /0000-0003-0761-1755/work/190474466
dc.identifier.urihttps://hdl.handle.net/2164/26525
dc.language.isoeng
dc.relation.ispartofMicrobiological Researchen
dc.subjectcaspofunginen
dc.subjectantimicrobial resistanceen
dc.subjectevolutionen
dc.subjectcell wallen
dc.subjectstress responseen
dc.subjectQR Microbiologyen
dc.subject.lccQRen
dc.titleIn vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulenceen
dc.typeJournal articleen

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