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Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure

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dc.contributor.authorJalal, Mohammed M
dc.contributor.authorWhyte, Claire S
dc.contributor.authorCoxon, Fraser P
dc.contributor.authorMutch, Nicola J
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Dental Educationen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.date.accessioned2023-05-17T15:15:00Z
dc.date.available2023-05-17T15:15:00Z
dc.date.issued2023
dc.descriptionAcknowledgments The authors thank the Microscopy and Histology Core Facility and the Iain Fraser Cytometry at the University of Aberdeen for excellent advice and use of facilities. The authors thank the Deanship of the Scientific Research at the University of Tabuk for supporting this work. Funding This study was supported by grants from the University of Tabuk, Tabuk, Saudi Arabia (M.M.J & N.J.M) (TBU126) and (S-1440-0311). The material of this manuscript has been formed part of a doctoral dissertation that is available online at the University of Aberdeen. C.S.W and N.J.M are supported by grants from the British Heart Foundation PG/15/82/31721 and PG/20/17/35050 and Tenovus Scotland Grampian, Highlands and Islands G17.03.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent7115279
dc.identifier242756742
dc.identifier5ca9a1b7-e7e8-456d-84d9-a0d7a49edc18
dc.identifier37139869
dc.identifier85159546726
dc.identifier.citationJalal, M M, Whyte, C S, Coxon, F P & Mutch, N J 2023, 'Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure', Platelets, vol. 34, no. 1, 2206921. https://doi.org/10.1080/09537104.2023.2206921en
dc.identifier.doi10.1080/09537104.2023.2206921
dc.identifier.iss1en
dc.identifier.issn0953-7104
dc.identifier.otherRIS: urn:5EDFD49A7B86157C5178D5ACACCD2948
dc.identifier.otherORCID: /0000-0002-7452-0813/work/169538834
dc.identifier.urihttps://hdl.handle.net/2164/20746
dc.identifier.vol34en
dc.language.isoeng
dc.relation.ispartofPlateletsen
dc.subjectFibrinen
dc.subjectplatelatesen
dc.subjectRab27ben
dc.subjectstatinsen
dc.subjectthrombosisen
dc.subjectR Medicineen
dc.subjectBritish Heart Foundationen
dc.subjectPG/15/82/31721en
dc.subjectPG/20/17/35050en
dc.subject.lccRen
dc.titleAtorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structureen
dc.typeJournal articleen

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