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Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

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dc.contributor.authorMeakin, Paul J.
dc.contributor.authorJalicy, Susan M.
dc.contributor.authorMontagut, Gemma
dc.contributor.authorAllsop, David J. P.
dc.contributor.authorCavellini, Daniella L.
dc.contributor.authorIrvine, Stuart W.
dc.contributor.authorMcGinley, Christopher
dc.contributor.authorLiddell, Mary K.
dc.contributor.authorMcNeilly, Alison D.
dc.contributor.authorParmionova, Karolina
dc.contributor.authorLiu, Yu-Ru
dc.contributor.authorBailey, Charlotte L. S.
dc.contributor.authorDale, J. Kim
dc.contributor.authorHeisler, Lora K.
dc.contributor.authorMcCrimmon, Rory J.
dc.contributor.authorAshford, Michael L. J.
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.date.accessioned2018-01-08T14:27:06Z
dc.date.available2018-01-08T14:27:06Z
dc.date.issued2018-01-08
dc.descriptionWe thank AstraZeneca for providing AZ-4217, Mark Smith (Imperial College, London) and Yuchio Yanagawa (Gunma University, Maebashi) for VGlut2-GFP and GAD67-GFP tissue, respectively. This work was funded by Medical Research Council (MR/K003291/1), Diabetes UK (12/0004458), British Heart Foundation (PG/15/44/31574) and Biotechnology and Biological Sciences Research Council CASE (with AstraZeneca) award (BB/I015663/1) to MLJA and by a grant to LKH from the Wellcome Trust (WT098012).en
dc.description.statusPeer revieweden
dc.format.extent2893850
dc.identifier114356986
dc.identifierf6908192-93a3-4042-aa94-3e2518686bec
dc.identifier85040460889
dc.identifier.citationMeakin, P J, Jalicy, S M, Montagut, G, Allsop, D J P, Cavellini, D L, Irvine, S W, McGinley, C, Liddell, M K, McNeilly, A D, Parmionova, K, Liu, Y-R, Bailey, C L S, Dale, J K, Heisler, L K, McCrimmon, R J & Ashford, M L J 2018, 'Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice', Scientific Reports, vol. 8, 55. https://doi.org/10.1038/s41598-017-18388-6en
dc.identifier.doi10.1038/s41598-017-18388-6
dc.identifier.issn2045-2322
dc.identifier.otherRIS: urn:9CD211481D5C8D9FD71BBEDF0705D41E
dc.identifier.otherRIS: Meakin2018
dc.identifier.urihttp://hdl.handle.net/2164/9874
dc.identifier.vol8en
dc.language.isoeng
dc.relation.ispartofScientific Reportsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjecthypothalamusen
dc.subjectobesityen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K003291/1en
dc.subjectBritish Heart Foundationen
dc.subjectPG/15/44/31574en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/I015663/1en
dc.subjectWellcome Trusten
dc.subjectWT098012en
dc.subject.lccRen
dc.titleBace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese miceen
dc.typeJournal articleen

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