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Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets

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dc.contributor.authorRasmussen, Tim
dc.contributor.authorRasmussen, Akiko
dc.contributor.authorYang, Limin
dc.contributor.authorKaul, Corinna
dc.contributor.authorBlack, Susan
dc.contributor.authorGalbiati, Heloisa
dc.contributor.authorConway, Stuart J
dc.contributor.authorMiller, Samantha
dc.contributor.authorBlount, Paul
dc.contributor.authorBooth, Ian Rylance
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2019-08-15T12:50:05Z
dc.date.available2019-08-15T12:50:05Z
dc.date.issued2019-08-09
dc.descriptionThe authors are grateful to Tony Lee (Southampton) and Jim Naismith (St Andrews and Oxford) for helpful discussions. IRB, SM, AR, TR, SB were supported by a Wellcome Programme Grant (WT092552MA); HG and CK were funded by the EU FP7 ITN programme NICHE. The MscS F151W mutant was created by N. J. Hayward during his PhD studies at the University of Aberdeen. We thank Vanessa Flegler for assistance in the electron microscopy experiment. IRB was a recipient of a Leverhulme Emeritus Research Fellowship and a CEMI research grant from Caltech; PB was supported by Grant I-1420 of the Welch Foundation and Grant GM121780 from the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or other funding organizations.en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent1531881
dc.identifier144507731
dc.identifier52ec5a6b-060a-4b44-8fbf-dbda78375792
dc.identifier85067174563
dc.identifier31173776
dc.identifier.citationRasmussen, T, Rasmussen, A, Yang, L, Kaul, C, Black, S, Galbiati, H, Conway, S J, Miller, S, Blount, P & Booth, I R 2019, 'Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets', Journal of Molecular Biology, vol. 431, no. 17, pp. 3339-3352. https://doi.org/10.1016/j.jmb.2019.05.043en
dc.identifier.doi10.1016/j.jmb.2019.05.043
dc.identifier.iss17en
dc.identifier.issn0022-2836
dc.identifier.otherMendeley: d5d22ccd-ab95-348d-944f-c62f09fe58ad
dc.identifier.otherORCID: /0000-0002-8223-9693/work/76974609
dc.identifier.urihttp://hdl.handle.net/2164/12721
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S002228361930333Xen
dc.identifier.urlhttp://www.mendeley.com/research/interaction-mechanosensitive-channel-mscs-membrane-bilayer-through-lipid-intercalation-grooves-pockeen
dc.identifier.vol431en
dc.language.isoeng
dc.relation.ispartofJournal of Molecular Biologyen
dc.subjectlipid-protein interactionen
dc.subjectfluorescence quenchingen
dc.subjectbrominated lipidsen
dc.subjecttension sensingen
dc.subjectelectrophysiologyen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subjectWT092552MAen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleInteraction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pocketsen
dc.typeJournal articleen

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