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Epac2 Elevation Reverses Inhibition by Chondroitin Sulfate Proteoglycans In Vitro and Transforms Postlesion Inhibitory Environment to Promote Axonal Outgrowth in an Ex Vivo Model of Spinal Cord Injury

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dc.contributor.authorGuijarro Belmar, Alba
dc.contributor.authorViskontas, Mindaugas
dc.contributor.authorWei, Yuting
dc.contributor.authorBo, Xuenong
dc.contributor.authorShewan, Derryck
dc.contributor.authorHuang, Wenlong
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2020-02-13T00:04:55Z
dc.date.available2020-02-13T00:04:55Z
dc.date.embargoedUntil2020-02-13
dc.date.issued2019-10-16
dc.descriptionThis work was supported by the International Spinal Research Trust, Scottish Rugby Union and RS McDonald Charitable Trust. We thank Professor Divya Chari for training with the ex vivo model. We also thank Dr Amer Syed, Ms Elena Moratal-Torres, Mr James W. Thomson, Ms Victoria Torsteinsbø and Dr Marieta Georgieva for their assistance with rheology and in vitro experiments.en
dc.description.statusPeer revieweden
dc.format.extent17
dc.format.extent5928059
dc.identifier146641854
dc.identifierb1ed5684-9b88-43d4-a2a6-922c4ebcd45c
dc.identifier31409666
dc.identifier000490521800016
dc.identifier85073488275
dc.identifier.citationGuijarro Belmar, A, Viskontas, M, Wei, Y, Bo, X, Shewan, D & Huang, W 2019, 'Epac2 Elevation Reverses Inhibition by Chondroitin Sulfate Proteoglycans In Vitro and Transforms Postlesion Inhibitory Environment to Promote Axonal Outgrowth in an Ex Vivo Model of Spinal Cord Injury', Journal of Neuroscience, vol. 39, no. 42, pp. 8330-8346. https://doi.org/10.1523/JNEUROSCI.0374-19.2019en
dc.identifier.doi10.1523/JNEUROSCI.0374-19.2019
dc.identifier.iss42en
dc.identifier.issn0270-6474
dc.identifier.otherMendeley: f944491c-c0c3-35eb-8f9d-8d5a91fe72f0
dc.identifier.urihttps://hdl.handle.net/2164/13690
dc.identifier.urlhttp://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0374-19.2019en
dc.identifier.urlhttp://www.mendeley.com/research/epac2-elevation-reverses-inhibition-chondroitin-sulfate-proteoglycans-vitro-transforms-postlesion-inen
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85073488275&partnerID=8YFLogxKen
dc.identifier.vol39en
dc.language.isoeng
dc.relation.ispartofJournal of Neuroscienceen
dc.subjectastrocyteen
dc.subjectaxonal growthen
dc.subjectcAMPen
dc.subjectEpac2en
dc.subjectorganotypicen
dc.subjectspinal cord injuryen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectGeneral Neuroscienceen
dc.subjectSupplementary Dataen
dc.subject.lccRC0321en
dc.titleEpac2 Elevation Reverses Inhibition by Chondroitin Sulfate Proteoglycans In Vitro and Transforms Postlesion Inhibitory Environment to Promote Axonal Outgrowth in an Ex Vivo Model of Spinal Cord Injuryen
dc.typeJournal articleen

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