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Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain

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dc.contributor.authorAl-Hilaly, Youssra K
dc.contributor.authorFoster, Bronwen E
dc.contributor.authorBiasetti, Luca
dc.contributor.authorLutter, Liisa
dc.contributor.authorPollack, Saskia J
dc.contributor.authorRickard, Janet E
dc.contributor.authorStorey, John M D
dc.contributor.authorHarrington, Charles R
dc.contributor.authorXue, Wei-Feng
dc.contributor.authorWischik, Claude M
dc.contributor.authorSerpell, Louise C
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2019-12-20T15:55:00Z
dc.date.available2019-12-20T15:55:00Z
dc.date.issued2020-03-01
dc.descriptionAcknowledgements We acknowledge Biochemical society for funding forBF. YA acknowledges Mustansiriyah University,Baghdad, Iraq (www.uomustansiriyah.edu.iq), for sup-port. We thank Pascale Schellenberger for valuablehelp and training with TEM. The human tissue wasprovided by the London Neurodegenerative DiseasesBrain Bank. Respectfully, we thank the anonymoustissue donors and their next of kin. We thank fundingfrom the BBSRC (BB/S003312/1, WFX and LCS) andthe EPSRC (EP/R513246/1, LL).Author contributionsYA managed the project, conceived the idea and pre-pared the samples. YA and BF collected and analysedthe TEM data; LB provided training and sectioned thebrain sample; YA, LL and WFX collected the AFMdata; and LL and WFX analysed the AFM data. JERprepared the purified dGAE protein. YA, BF and LSwrote the first draft and all authors reviewed themanuscript and approved the final version. CH, CWand LS managed the overall project. Ethics AD brain tissue was provided by the London Neu-rodegenerative Diseases Brain Bank, Institute of Psy-chiatry, King’s College, London, under Local EthicsCommittee guidelines, and informed consent for braindonation was obtained from the next of kin by theLondon Neurodegenerative Diseases Brain Bank.en
dc.description.statusPeer revieweden
dc.format.extent7
dc.format.extent1121063
dc.identifier153094830
dc.identifier63643b6d-e8d0-4e07-a87c-36d1b19f9107
dc.identifier31721178
dc.identifier85075938961
dc.identifier.citationAl-Hilaly, Y K, Foster, B E, Biasetti, L, Lutter, L, Pollack, S J, Rickard, J E, Storey, J M D, Harrington, C R, Xue, W-F, Wischik, C M & Serpell, L C 2020, 'Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain', FEBS LETTERS, vol. 594, no. 5, pp. 944-950. https://doi.org/10.1002/1873-3468.13675en
dc.identifier.doi10.1002/1873-3468.13675
dc.identifier.iss5en
dc.identifier.issn0014-5793
dc.identifier.otherORCID: /0000-0002-5261-5467/work/73579166
dc.identifier.otherORCID: /0000-0003-2250-3920/work/173415868
dc.identifier.urihttps://hdl.handle.net/2164/13414
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85075938961&partnerID=8YFLogxKen
dc.identifier.vol594en
dc.language.isoeng
dc.relation.ispartofFEBS LETTERSen
dc.subjectAlzheimer’s diseaseen
dc.subjectneurofibrillary tanglesen
dc.subjectpaired helical filamentsen
dc.subjecttauen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectGeneticsen
dc.subjectMolecular Biologyen
dc.subjectBiophysicsen
dc.subjectStructural Biologyen
dc.subjectBiochemistryen
dc.subjectCell Biologyen
dc.subjectEngineering and Physical Sciences Research Council (EPSRC)en
dc.subjectEP/R513246/1, LLen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/S003312/en
dc.subject.lccRC0321en
dc.titleTau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brainen
dc.typeJournal articleen

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