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Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

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dc.contributor.authorMartínez-López, María
dc.contributor.authorIborra, Salvador
dc.contributor.authorConde-Garrosa, Ruth
dc.contributor.authorMastrangelo, Annalaura
dc.contributor.authorDanne, Camille
dc.contributor.authorMann, Elizabeth R
dc.contributor.authorReid, Delyth M
dc.contributor.authorGaboriau-Routhiau, Valérie
dc.contributor.authorChaparro, Maria
dc.contributor.authorLorenzo, María P
dc.contributor.authorMinnerup, Lara
dc.contributor.authorSaz-Leal, Paula
dc.contributor.authorSlack, Emma
dc.contributor.authorKemp, Benjamin
dc.contributor.authorGisbert, Javier P
dc.contributor.authorDzionek, Andrzej
dc.contributor.authorRobinson, Matthew J
dc.contributor.authorRupérez, Francisco J
dc.contributor.authorCerf-Bensussan, Nadine
dc.contributor.authorBrown, Gordon D
dc.contributor.authorBernardo, David
dc.contributor.authorLeibundGut-Landmann, Salomé
dc.contributor.authorSancho, David
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2019-03-04T17:10:08Z
dc.date.available2019-03-04T17:10:08Z
dc.date.issued2019-02-19
dc.descriptionWe are grateful to members of the D.S. laboratory and Dr. E. Fernández-Malavé for discussions and critical reading of the manuscript. We appreciate the support of A. Tomás-Loba, G. Sabio, P. Martín, A. Tsilingiri, A.R. Ramiro, C.L. Abram, C.A. Lowell, J.M. García-Lobo, M. Molina, and M.C. Rodríguez for providing reagents and support. We thank the staff at the Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) facilities for technical support. M.M.-L. received a Formación de Personal Universitario (FPU) fellowship (AP2010-5935) from the Spanish Ministerio de Educación. S.I. is funded by grant SAF2015-74561-JIN from the Spanish Ministerio de Ciencia, Innovación, y Universidades (MCIU) and Fondos Europeos de Desarrollo Regional (FEDER). G.D.B and D.M.R. are supported by the Wellcome Trust and the MRC Centre for Medical Mycology at the University of Aberdeen. S.L.L. is supported by the Swiss National Science Foundation (PP00P3_150758). Work in the D.S. laboratory is funded by the CNIC and grant SAF2016-79040-R from MCIU, the Agencia Estatal de Investigación, and FEDER; B2017/BMD-3733 Immunothercan-CM from Comunidad de Madrid; RD16/0015/0018-REEM from FIS-Instituto de Salud Carlos III, MCIU, and FEDER; the Acteria Foundation; the Constantes y Vitales prize (Atresmedia); La Marató de TV3 Foundation (201723); the European Commission (635122-PROCROP H2020), and the European Research Council (ERC-2016-Consolidator Grant 725091). The CNIC is supported by the MCIU and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent4400993
dc.identifier142295018
dc.identifierd63e672d-b212-40b8-bf4c-e294d3886581
dc.identifier30709742
dc.identifier85061393496
dc.identifier000459006700018
dc.identifier.citationMartínez-López, M, Iborra, S, Conde-Garrosa, R, Mastrangelo, A, Danne, C, Mann, E R, Reid, D M, Gaboriau-Routhiau, V, Chaparro, M, Lorenzo, M P, Minnerup, L, Saz-Leal, P, Slack, E, Kemp, B, Gisbert, J P, Dzionek, A, Robinson, M J, Rupérez, F J, Cerf-Bensussan, N, Brown, G D, Bernardo, D, LeibundGut-Landmann, S & Sancho, D 2019, 'Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity', Immunity, vol. 50, no. 2, pp. 446-461. https://doi.org/10.1016/j.immuni.2018.12.020en
dc.identifier.doi10.1016/j.immuni.2018.12.020
dc.identifier.iss2en
dc.identifier.issn1074-7613
dc.identifier.otherMendeley: 1b14beec-5376-3901-88d6-c6207279d6d9
dc.identifier.urihttp://hdl.handle.net/2164/11998
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85061393496&partnerID=8YFLogxKen
dc.identifier.urlhttp://www.mendeley.com/research/microbiota-sensing-minclesyk-axis-dendritic-cells-regulates-interleukin17-22-production-promotes-int-1en
dc.identifier.vol50en
dc.language.isoeng
dc.relation.ispartofImmunityen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectintestinal barrieren
dc.subjectdendritic cellen
dc.subjectT lymphocyteen
dc.subjectinnate lymphoid cellsen
dc.subjectMinkleen
dc.subjectSyk kinaseen
dc.subjectIL-17en
dc.subjectIL-22en
dc.subjectantimicrobial defenseen
dc.subjectgut microbiota translocationen
dc.subjectliver inflammationen
dc.subjectlipid metabolismen
dc.subjectMincleen
dc.subjectIGAen
dc.subjectC-TYPE LECTINen
dc.subjectCOMMENSAL BACTERIAen
dc.subjectROR-GAMMA-Ten
dc.subjectPEYERS-PATCHESen
dc.subjectINDUCTIONen
dc.subjectINNATE LYMPHOID-CELLSen
dc.subjectADAPTIVE IMMUNITYen
dc.subjectT(H)17 CELLSen
dc.subjectDIFFERENTIATIONen
dc.subjectR Medicineen
dc.subjectInfectious Diseasesen
dc.subjectImmunology and Allergyen
dc.subjectImmunologyen
dc.subject.lccRen
dc.titleMicrobiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrityen
dc.typeJournal articleen

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