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Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies

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dc.contributor.authorMayer, Claus-Dieter
dc.contributor.authorde La Giclais, Soizick Magon
dc.contributor.authorAlsehly, Fozan
dc.contributor.authorHoppler, Stefan
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2020-05-14T12:35:01Z
dc.date.available2020-05-14T12:35:01Z
dc.date.issued2020-05
dc.descriptionFunding: CM acknowledges funding from the Scottish Government: Rural & Environment Science & Analytical Services. (RESAS). SH is a Royal Society/Leverhulme Trust Senior Research Fellow (SRF\R1\191017) and acknowledges research funding from the Biotechnology and Biological Sciences Research Council (BB/S018190/1, BB/M001695/1). Author Contributions: C.-D.M. and S.H. had conceived and supervised this project; C.-D.M. curated the data and carried out some analysis; S.M.L.G., carried out most of the analysis; F.A. wrote an original draft together with Stefan Hoppler. All authors have read and agreed to the published version of the manuscript. Supplementary Materials: The following are available online at www.mdpi.com/2073-4425/11/5/538/s1: Figure S1: Principal Component Analysis of selected studies, Figure S2: Principal Component Analysis of de-selected study, Table S1: Transcriptomics Data (Correlation Coefficients) Table S1A: Transcript correlation between eight selected genes (TCF7, LEF1, TCF7L1, TCF7L2, AXIN2, DKK1, FZD7, LGR5); Table S1B: The TCF7-correlated transcriptome; Table S1C: The LEF1correlated transcriptome; Table S1D: The TCF7L1-correlated transcriptome; Table S1E: The TCF7L2-correlated transcriptome; Table S1F: The AXIN2-correlated transcriptome; Table S1G: The DKK1-correlated transcriptome; Table S1H: The FZD7-correlated transcriptome; Table S1I: The LGR5-correlated transcriptome; Table S1J: Differences in LEF/TCF-correlated transcriptomes; Table S1K: Differences between AXIN2- and LEF/TCF-correlated transcriptomes, Table S2: Correlated Transcriptome in normal and tumor tissue, Table S3: Comparison of LEF/TCF-correlated transcriptomes, Table S4: Differences between AXIN1- and LEF/TCF-correlated transcriptomes.en
dc.description.statusPeer revieweden
dc.format.extent23
dc.format.extent2729659
dc.identifier162667852
dc.identifier19f4413b-2da6-469a-86b5-41bca13df95f
dc.identifier85084626943
dc.identifier32403323
dc.identifier000542276700041
dc.identifier.citationMayer, C-D, de La Giclais, S M, Alsehly, F & Hoppler, S 2020, 'Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies', Genes, vol. 11, no. 5, 538. https://doi.org/10.3390/genes11050538en
dc.identifier.doi10.3390/genes11050538
dc.identifier.iss5en
dc.identifier.issn2073-4425
dc.identifier.urihttps://hdl.handle.net/2164/14315
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85084626943&partnerID=8YFLogxKen
dc.identifier.urlhttp://www.mdpi.com/2073-4425/11/5/538/s1en
dc.identifier.vol11en
dc.language.isoeng
dc.relation.ispartofGenesen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectWnten
dc.subjectcolorectal canceren
dc.subjectTCFen
dc.subjectLEFen
dc.subjecttranscriptomeen
dc.subjectHUMAN COLONen
dc.subjectTARGETen
dc.subjectSTEM-CELLSen
dc.subjectPROTEINen
dc.subjectCYCLIN D1en
dc.subjectBETA-CATENINen
dc.subjectNEGATIVE REGULATORen
dc.subjectOVEREXPRESSIONen
dc.subjectGENEen
dc.subjectSIGNALING PATHWAYen
dc.subjectColorectal canceren
dc.subjectTranscriptomeen
dc.subjectQH426 Geneticsen
dc.subjectR Medicine (General)en
dc.subjectGenetics(clinical)en
dc.subjectGeneticsen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/M001695/1en
dc.subjectBB/S018190/1en
dc.subjectRural and Environmental Science and Analytical Services (RESAS)en
dc.subjectSupplementary Dataen
dc.subject.lccQH426en
dc.subject.lccR1en
dc.titleDiverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsiesen
dc.typeJournal articleen

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