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Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris

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dc.contributor.authorBruno, Mariolina
dc.contributor.authorKersten, Simone
dc.contributor.authorBain, Judith M.
dc.contributor.authorJaeger, Martin
dc.contributor.authorRosati, Diletta
dc.contributor.authorKruppa, Michael D
dc.contributor.authorLowman, Douglas W.
dc.contributor.authorRice, Peter J.
dc.contributor.authorGraves, Bridget
dc.contributor.authorZuchao, Ma
dc.contributor.authorNing Jiao, Y.
dc.contributor.authorChowdhary, Anuradha
dc.contributor.authorRenieris, George
dc.contributor.authorvan de Veerdonk, Frank L
dc.contributor.authorKullberg, Bart-Jan
dc.contributor.authorGiamarellos-Bourboulis, Evangelos J.
dc.contributor.authorHoischen, Alexander
dc.contributor.authorGow, Neil A.R.
dc.contributor.authorBrown, Alistair J.P.
dc.contributor.authorMeis, Jacques F.
dc.contributor.authorWilliams, David L
dc.contributor.authorNetea, Mihai G.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2021-02-24T00:08:15Z
dc.date.available2021-02-24T00:08:15Z
dc.date.embargoedUntil2021-02-24
dc.date.issued2020-12
dc.descriptionACKNOWLEDGMENTS: We would like to thank Trees Jansen for performing the initial pilot experiments and Ilse Curfs-Breuker and Dirk Faro for their support at the CWZ hospital. We thank Charlotte Kaffa, BSc. for her technical assistance. We would like to thank Vinod Kumar for his input during the transcriptomic data analysis, Mark Gresnigt for the in vitro experimental suggestions and Anouk Becker for the help during the revision experiments. AJPB and NARG thank the MRC (MR/M026663/1) and Wellcome for support and the Medical Research Council (MRC) Centre for Medical Mycology at the University of Aberdeen (MR/N006364/1). A.H. and S.K. were supported by the Radboud Institute for Molecular Life Sciences. Part of the study was supported by the Hellenic Institute for the Study of Sepsis. D.L.W. was supported by National Institutes of Health grants NIH GM083016, GM119197 and C06RR0306551. M.G.N. was supported by an ERC Advanced Grant (no. 833247) and a Spinoza Grant from the Netherlands Organization for Scientific Research.en
dc.description.statusPeer revieweden
dc.format.extent16
dc.format.extent493162
dc.identifier172854191
dc.identifierf405f292-770a-475d-939a-cf97ee82258f
dc.identifier32839538
dc.identifier85089747478
dc.identifier000562728000003
dc.identifier.citationBruno, M, Kersten, S, Bain, J M, Jaeger, M, Rosati, D, Kruppa, M D, Lowman, D W, Rice, P J, Graves, B, Zuchao, M, Ning Jiao, Y, Chowdhary, A, Renieris, G, van de Veerdonk, F L, Kullberg, B-J, Giamarellos-Bourboulis, E J, Hoischen, A, Gow, N A R, Brown, A J P, Meis, J F, Williams, D L & Netea, M G 2020, 'Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris', Nature Microbiology, vol. 5, pp. 1516-1531. https://doi.org/10.1038/s41564-020-0780-3en
dc.identifier.doi10.1038/s41564-020-0780-3
dc.identifier.issn2058-5276
dc.identifier.otherORCID: /0000-0002-1060-0419/work/112075857
dc.identifier.urihttps://hdl.handle.net/2164/15916
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85089747478&partnerID=8YFLogxKen
dc.identifier.vol5en
dc.language.isoeng
dc.relation.ispartofNature Microbiologyen
dc.subjectfungal host responseen
dc.subjectfungal infectionen
dc.subjectYEASTen
dc.subjectSURVIVALen
dc.subjectLECTINen
dc.subjectRECOGNITIONen
dc.subjectALBICANSen
dc.subjectMANNANen
dc.subjectRESISTANT CANDIDA-AURISen
dc.subjectEMERGENCEen
dc.subjectGLUCANen
dc.subjectQR Microbiologyen
dc.subjectQ Science (General)en
dc.subjectR Medicineen
dc.subjectApplied Microbiology and Biotechnologyen
dc.subjectMicrobiology (medical)en
dc.subjectGeneticsen
dc.subjectCell Biologyen
dc.subjectMicrobiologyen
dc.subjectImmunologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subjectMR/M026663/1en
dc.subjectEuropean Research Councilen
dc.subject833247en
dc.subjectWellcome Trusten
dc.subjectSupplementary Dataen
dc.subject.lccQRen
dc.subject.lccQ1en
dc.subject.lccRen
dc.titleTranscriptional and functional insights into the host immune response against the emerging fungal pathogen Candida aurisen
dc.typeJournal articleen

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