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Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis

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dc.contributor.authorRudkin, Fiona M
dc.contributor.authorRaziunaite, Ingrida
dc.contributor.authorWorkman, Hillary
dc.contributor.authorEssono, Sosthene
dc.contributor.authorBelmonte, Rodrigo
dc.contributor.authorMacCallum, Donna M
dc.contributor.authorJohnson, Elizabeth M
dc.contributor.authorSilva, Lisete M
dc.contributor.authorPalma, Angelina S
dc.contributor.authorFeizi, Ten
dc.contributor.authorJensen, Allan
dc.contributor.authorErwig, Lars P
dc.contributor.authorGow, Neil A. R.
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2019-01-07T11:30:05Z
dc.date.available2019-01-07T11:30:05Z
dc.date.issued2018-12-11
dc.descriptionWe thank the BBSRC, SULSA BioSKAPE and Pfizer Inc. for funding for a studentship for F.M.R. and the Wellcome Trust (086827, 075470, 099215, 099197 and 101873) and a Wellcome Trust ISSF award (105625), MRC CiC (MC_PC_14114) and MRC Centre for Medical Mycology and University of Aberdeen for funding and a Wellcome Trust Strategic Award (097377) and a Wellcome Trust grant 099197MA to T.F. and FCT Investigator IF/00033/2012 and PTDC/QUI-QUI/112537/2009 to A.S.P. We thank Ian Broadbent, Angus McDonald and Ron Gladue for constructive discussions; Chris Boston and Amanda Fitzgerald for advice on antibody expression and purification; Ed Lavallie and Wayne Stochaj for design and expression of the recombinant Hyr1; Louise Walker for high-pressure freezing of samples for TEM analysis; Jeanette Wagener for endotoxin testing of mAbs for in vivo experiments; Yan Liu of the Glycosciences laboratory for insight in the analysis with N-glycan array; Rebecca Hall and Mark Gresnigt for providing fungal strains; Andrew Limper and Theodore J. Kottom for providing Pneumocystis infected lung tissue extracts; David Williams for C. albicans mannoprotein; Christopher Thornton for A. fumigatus mannoprotein; Katie J. Doores for mAb PGT 128; and Gordon Brown for the murine Fc-Dectin-1. We are grateful to Lucinda Wight, Debbie Wilkinson and Kevin MacKenzie in the Microscopy and Histology Core Facility (Aberdeen University) and Raif Yuecel in the Iain Fraser Cytometry Centre (Aberdeen University) for their expert help with microscopy and cytometry experiments. We are also grateful to the staff at the University of Aberdeen Medical Research Facility for assistance with in vivo experiments and members of the Glycosciences Laboratory for their support of the Carbohydrate Microarray Facility. 18 January 2019 - Author Correction: Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis F. M. Rudkin, I. Raziunaite, H. Workman, S. Essono, R. Belmonte, D. M. MacCallum, E. M. Johnson, L. Silva, A. S. Palma, T. Feizi, A. Jensen, L. P. Erwig & N. A. R. Gow Nature Communicationsvolume 10, Article number: 394 (2019)en
dc.description.statusPeer revieweden
dc.format.extent16
dc.format.extent2381159
dc.identifier141232823
dc.identifier02fef690-a9eb-4a06-b913-e6ffbb88fb42
dc.identifier30538246
dc.identifier85058242231
dc.identifier.citationRudkin, F M, Raziunaite, I, Workman, H, Essono, S, Belmonte, R, MacCallum, D M, Johnson, E M, Silva, L M, Palma, A S, Feizi, T, Jensen, A, Erwig, L P & Gow, N A R 2018, 'Single human B cell-derived monoclonal anti- Candida antibodies enhance phagocytosis and protect against disseminated candidiasis', Nature Communications, vol. 9, 5288. https://doi.org/10.1038/s41467-018-07738-1en
dc.identifier.doi10.1038/s41467-018-07738-1
dc.identifier.issn2041-1723
dc.identifier.otherPubMedCentral: PMC6290022
dc.identifier.otherORCID: /0000-0003-4833-0378/work/54384683
dc.identifier.otherORCID: /0000-0002-1541-3372/work/76975923
dc.identifier.urihttp://hdl.handle.net/2164/11735
dc.identifier.vol9en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectQR Microbiologyen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectWellcome Trusten
dc.subject086827en
dc.subject075470en
dc.subject099215en
dc.subject099197en
dc.subject101873en
dc.subject105625en
dc.subject097377en
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_PC_14114en
dc.subjectSupplementary Dataen
dc.subject.lccQRen
dc.titleSingle human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasisen
dc.typeJournal articleen

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