University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Simple item page
dc.contributor.authorJansen, Jitske
dc.contributor.authorReimer, Katharina C.
dc.contributor.authorNagai, James S.
dc.contributor.authorVarghese, Finny S.
dc.contributor.authorOverheul, Gijs J.
dc.contributor.authorde Beer, Marit
dc.contributor.authorRoverts, Rona
dc.contributor.authorDaviran, Deniz
dc.contributor.authorFermin, Liline A.S.
dc.contributor.authorWillemsen, Brigith
dc.contributor.authorBeukenboom, Marcel
dc.contributor.authorDjudjaj, Sonja
dc.contributor.authorvon Stillfried, Saskia
dc.contributor.authorvan Eijk, Larissa E.
dc.contributor.authorMastik, Mirjam
dc.contributor.authorBulthuis, Marian
dc.contributor.authorDunnen, Wilfred den
dc.contributor.authorvan Goor, Harry
dc.contributor.authorHillebrands, Jan-Luuk
dc.contributor.authorTriana, Sergio H.
dc.contributor.authorAlexandrov, Theodore
dc.contributor.authorTimm, Marie-Cherelle
dc.contributor.authorvan den Berge, Bartholomeus T.
dc.contributor.authorvan den Broek, Martijn
dc.contributor.authorNlandu, Quincy
dc.contributor.authorHeijnert, Joelle
dc.contributor.authorBindels, Eric M.J.
dc.contributor.authorHoogenboezem, Remco M.
dc.contributor.authorMooren, Fieke
dc.contributor.authorKuppe, Christoph
dc.contributor.authorMiesen, Pascal
dc.contributor.authorGrünberg, Katrien
dc.contributor.authorIjzermans, Ties
dc.contributor.authorSteenbergen, Eric J.
dc.contributor.authorCzogalla, Jan
dc.contributor.authorSchreuder, Michiel F.
dc.contributor.authorSommerdijk, Nico
dc.contributor.authorAkiva, Anat
dc.contributor.authorBoor, Peter
dc.contributor.authorPuelles, Victor G.
dc.contributor.authorFloege, Jürgen
dc.contributor.authorHuber, Tobias B.
dc.contributor.authorAchdout, Hagit
dc.contributor.authorAimon, Anthony
dc.contributor.authorBar-David, Elad
dc.contributor.authorBarr, Haim
dc.contributor.authorBen-Shmuel, Amir
dc.contributor.authorBennett, James
dc.contributor.authorBoby, Melissa L.
dc.contributor.authorBorden, Bruce
dc.contributor.authorBowman, Gregory R.
dc.contributor.authorBrun, Juliane
dc.contributor.authorBVNBS, Sarma
dc.contributor.authorCalmiano, Mark
dc.contributor.authorCarbery, Anna
dc.contributor.authorCattermole, Emma
dc.contributor.authorChernychenko, Eugene
dc.contributor.authorChoder, John D.
dc.contributor.authorClyde, Austin
dc.contributor.authorCoffland, Joseph E.
dc.contributor.authorCohen, Galit
dc.contributor.authorCole, Jason
dc.contributor.authorContini, Alessandro
dc.contributor.authorCox, Lisa
dc.contributor.authorCvitkovic, Milan
dc.contributor.authorDias, Alex
dc.contributor.authorDonckers, Kim
dc.contributor.authorDotson, David L.
dc.contributor.authorDouangamath, Alica
dc.contributor.authorDuberstein, Shirly
dc.contributor.authorDudgeon, Tim
dc.contributor.authorDunnett, Louise
dc.contributor.authorEastman, Peter K.
dc.contributor.authorErez, Noam
dc.contributor.authorEyermann, Charles J.
dc.contributor.authorFairhead, Mike
dc.contributor.authorFate, Gwen
dc.contributor.authorFearon, Daren
dc.contributor.authorFederov, Oleg
dc.contributor.authorFerla, Matteo
dc.contributor.authorFernandes, Rafaela S.
dc.contributor.authorFerrins, Lori
dc.contributor.authorFoster, Richard
dc.contributor.authorFoster, Holly
dc.contributor.authorGabizon, Ronen
dc.contributor.authorGarcia-Sastre, Adolfo
dc.contributor.authorGawriljuk, Victor O.
dc.contributor.authorGehrtz, Paul
dc.contributor.authorGileadi, Carina
dc.contributor.authorGiroud, Charline
dc.contributor.authorGlass, William G.
dc.contributor.authorGlen, Robert
dc.contributor.authorglinert, Itai
dc.contributor.authorGodoy, Andre S.
dc.contributor.authorGorichko, Marian
dc.contributor.authorGorrie-Stone, Tyler
dc.contributor.authorGriffen, Ed J.
dc.contributor.authorHart, Storm Hassell
dc.contributor.authorHeer, Jag
dc.contributor.authorHenry, Micheal
dc.contributor.authorHill, Michelle
dc.contributor.authorHorrell, Sam
dc.contributor.authorHurley, Matthew F.D.
dc.contributor.authorIsraely, Tomer
dc.contributor.authorJajack, Andrew
dc.contributor.authorJnoff, Eric
dc.contributor.authorJochmans, Dirk
dc.contributor.authorJohn, Tobias
dc.contributor.authorDe Jonghe, Steven
dc.contributor.authorKantsadi, Anastassia L.
dc.contributor.authorKenny, Peter W.
dc.contributor.authorKiappes, J.L.
dc.contributor.authorKoekemoer, Lizbe
dc.contributor.authorKovar, Boris
dc.contributor.authorKrojer, Tobias
dc.contributor.authorLee, Alpha A.
dc.contributor.authorLefker, Bruce A.
dc.contributor.authorLevy, Haim
dc.contributor.authorLondon, Nir
dc.contributor.authorLukacik, Petra
dc.contributor.authorMacdonald, Hannah Bruce
dc.contributor.authorMaclean, Beth
dc.contributor.authorMalla, Tika R.
dc.contributor.authorMatviiuk, Tatiana
dc.contributor.authorMcCorkindale, Willam
dc.contributor.authorMcGovern, Briana L.
dc.contributor.authorMelamed, Sharon
dc.contributor.authorMichurin, Oleg
dc.contributor.authorMikolajek, Halina
dc.contributor.authorMilne, Bruce F.
dc.contributor.authorMorris, Aaron
dc.contributor.authorMorris, Garret M.
dc.contributor.authorMorwitzer, Melody Jane
dc.contributor.authorMoustakas, Demetri
dc.contributor.authorNakamura, Aline M.
dc.contributor.authorNeto, Jose Brandao
dc.contributor.authorNeyts, Johan
dc.contributor.authorNguyen, Luong
dc.contributor.authorNoske, Gabriela D.
dc.contributor.authorOleinikovas, Vladas
dc.contributor.authorOliva, Glaucius
dc.contributor.authorOwen, David
dc.contributor.authorPsenak, Vladimir
dc.contributor.authorPai, Ruby
dc.contributor.authorPan, Jin
dc.contributor.authorParan, Nir
dc.contributor.authorPerry, Benjamin
dc.contributor.authorPingle, Maneesh
dc.contributor.authorPinjari, Jakir
dc.contributor.authorPoliti, Boaz
dc.contributor.authorPowell, Ailsa
dc.contributor.authorPuni, Reut
dc.contributor.authorRangel, Victor L.
dc.contributor.authorReddi, Ranbabu N.
dc.contributor.authorReid, St Patrick
dc.contributor.authorResnick, Efrat
dc.contributor.authorRipka, Emily Grace
dc.contributor.authorRobinson, Matthew C.
dc.contributor.authorRobinson, Ralph P.
dc.contributor.authorRodriguez-Guerra, Jaime
dc.contributor.authorRosales, Romel
dc.contributor.authorRufa, Dominic
dc.contributor.authorSchofield, Chris
dc.contributor.authorShafeev, Mikhail
dc.contributor.authorShaikh, Aarif
dc.contributor.authorShi, Jiye
dc.contributor.authorShurrush, Khriesto
dc.contributor.authorSing, Sukrit
dc.contributor.authorSittner, Assa
dc.contributor.authorSkyner, Rachael
dc.contributor.authorSmalley, Adam
dc.contributor.authorSmilova, Mihaela D.
dc.contributor.authorSolmesky, Leonardo J.
dc.contributor.authorSpencer, John
dc.contributor.authorStrain-Damarell, Claire
dc.contributor.authorSwamy, Vishwanath
dc.contributor.authorTamir, Hadas
dc.contributor.authorTennant, Rachael
dc.contributor.authorThompson, Warren
dc.contributor.authorThompson, Andrew
dc.contributor.authorTomasia, Susana
dc.contributor.authorTumber, Anthony
dc.contributor.authorVakonakis, Ioannis
dc.contributor.authorvan Rij, Ronald P.
dc.contributor.authorvan Geel, Laura
dc.contributor.authorVaschetto, Mariana
dc.contributor.authorVitner, Einat B.
dc.contributor.authorVoelz, Vincent
dc.contributor.authorVolkamer, Andra
dc.contributor.authorvon Delft, Frank
dc.contributor.authorvon Delft, Annette
dc.contributor.authorWalsh, Martin
dc.contributor.authorWard, Walter
dc.contributor.authorWeatherall, Charlie
dc.contributor.authorWeiss, Shay
dc.contributor.authorWhite, Kris M.
dc.contributor.authorWild, Conor Francis
dc.contributor.authorWittmann, Matthew
dc.contributor.authorWright, Nathan
dc.contributor.authorYahalom-Ronen, Yfat
dc.contributor.authorZaidmann, Daniel
dc.contributor.authorZidane, Hadeer
dc.contributor.authorZitzmann, Nicole
dc.contributor.authorCosta, Ivan G.
dc.contributor.authorSchneider, Rebekka K.
dc.contributor.authorSmeets, Bart
dc.contributor.authorKramann, Rafael
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.date.accessioned2023-04-13T14:53:01Z
dc.date.available2023-04-13T14:53:01Z
dc.date.issued2022-02-03
dc.descriptionThis work was supported by grants of the German Research Foundation (DFG: KR 4073/11-1; SFBTRR219, 322900939; and CRU344, 428857858, and CRU5011 InteraKD 445703531), a grant of the European Research Council (ERC-StG 677448), the Federal Ministry of Research and Education (BMBF NUM-COVID19, Organo-Strat 01KX2021), the Dutch Kidney Foundation (DKF) TASK FORCE consortium (CP1805), the Else Kroener Fresenius Foundation (2017_A144), and the ERA-CVD MENDAGE consortium (BMBF 01KL1907) all to R.K.; DFG (CRU 344, Z to I.G.C and CRU344 P2 to R.K.S.); and the BMBF eMed Consortium Fibromap (to V.G.P, R.K., R.K.S., and I.G.C.). R.K.S received support from the KWF Kankerbestrijding (11031/2017–1, Bas Mulder Award) and a grant by the ERC (deFiber; ERC-StG 757339). J.J. is supported by the Netherlands Organisation for Scientific Research (NWO Veni grant no: 091 501 61 81 01 36) and the DKF (grant no. 19OK005). B.S. is supported by the DKF (grant: 14A3D104) and the NWO (VIDI grant: 016.156.363). R.P.V.R. and G.J.O. are supported by the NWO VICI (grant: 16.VICI.170.090). P.B. is supported by the BMBF (DEFEAT PANDEMIcs, 01KX2021), the Federal Ministry of Health (German Registry for COVID-19 Autopsies-DeRegCOVID, www.DeRegCOVID.ukaachen.de; ZMVI1-2520COR201), and the German Research Foundation (DFG; SFB/TRR219 Project-IDs 322900939 and 454024652). S.D. received DFG support (DJ100/1-1) as well as support from VGP and TBH (SFB1192). M.d.B,R.R., N.S., and A.A. are supported by an ERC Advanced Investigator grant (H2020-ERC-2017-ADV-788982-COLMIN) to N.S. A.A. is supported by the NWO (VI.Veni.192.094). We thank Saskia de Wildt, Jeanne Pertijs (Radboudumc, Department of Pharmacology), and Robert M. Verdijk (Erasmus Medical Center, Department of Pathology) for providing tissue controls (Erasmus MC Tissue Bank) and Christian Drosten (Charite´ Universitatsmedizin Berlin, Institute of € Virology) and Bart Haagmans (Erasmus Medical Center, Rotterdam) for providing the SARS-CoV-2 isolate. We thank Kioa L. Wijnsma (Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children’s Hospital, Radboud University Medical Center) for support with statistical analysis regarding the COVID-19 patient cohort.en
dc.description.statusPeer revieweden
dc.format.extent24
dc.format.extent162501
dc.identifier219387484
dc.identifiere176afb5-e01d-45ba-ba11-f5e31d9e65c3
dc.identifier85123016842
dc.identifier.citationJansen, J, Reimer, K C, Nagai, J S, Varghese, F S, Overheul, G J, de Beer, M, Roverts, R, Daviran, D, Fermin, L A S, Willemsen, B, Beukenboom, M, Djudjaj, S, von Stillfried, S, van Eijk, L E, Mastik, M, Bulthuis, M, Dunnen, W D, van Goor, H, Hillebrands, J-L, Triana, S H, Alexandrov, T, Timm, M-C, van den Berge, B T, van den Broek, M, Nlandu, Q, Heijnert, J, Bindels, E M J, Hoogenboezem, R M, Mooren, F, Kuppe, C, Miesen, P, Grünberg, K, Ijzermans, T, Steenbergen, E J, Czogalla, J, Schreuder, M F, Sommerdijk, N, Akiva, A, Boor, P, Puelles, V G, Floege, J, Huber, T B, Achdout, H, Aimon, A, Bar-David, E, Barr, H, Ben-Shmuel, A, Bennett, J, Boby, M L, Borden, B, Bowman, G R, Brun, J, BVNBS, S, Calmiano, M, Carbery, A, Cattermole, E, Chernychenko, E, Choder, J D, Clyde, A, Coffland, J E, Cohen, G, Cole, J, Contini, A, Cox, L, Cvitkovic, M, Dias, A, Donckers, K, Dotson, D L, Douangamath, A, Duberstein, S, Dudgeon, T, Dunnett, L, Eastman, P K, Erez, N, Eyermann, C J, Fairhead, M, Fate, G, Fearon, D, Federov, O, Ferla, M, Fernandes, R S, Ferrins, L, Foster, R, Foster, H, Gabizon, R, Garcia-Sastre, A, Gawriljuk, V O, Gehrtz, P, Gileadi, C, Giroud, C, Glass, W G, Glen, R, glinert, I, Godoy, A S, Gorichko, M, Gorrie-Stone, T, Griffen, E J, Hart, S H, Heer, J, Henry, M, Hill, M, Horrell, S, Hurley, M F D, Israely, T, Jajack, A, Jnoff, E, Jochmans, D, John, T, De Jonghe, S, Kantsadi, A L, Kenny, P W, Kiappes, J L, Koekemoer, L, Kovar, B, Krojer, T, Lee, A A, Lefker, B A, Levy, H, London, N, Lukacik, P, Macdonald, H B, Maclean, B, Malla, T R, Matviiuk, T, McCorkindale, W, McGovern, B L, Melamed, S, Michurin, O, Mikolajek, H, Milne, B F, Morris, A, Morris, G M, Morwitzer, M J, Moustakas, D, Nakamura, A M, Neto, J B, Neyts, J, Nguyen, L, Noske, G D, Oleinikovas, V, Oliva, G, Owen, D, Psenak, V, Pai, R, Pan, J, Paran, N, Perry, B, Pingle, M, Pinjari, J, Politi, B, Powell, A, Puni, R, Rangel, V L, Reddi, R N, Reid, S P, Resnick, E, Ripka, E G, Robinson, M C, Robinson, R P, Rodriguez-Guerra, J, Rosales, R, Rufa, D, Schofield, C, Shafeev, M, Shaikh, A, Shi, J, Shurrush, K, Sing, S, Sittner, A, Skyner, R, Smalley, A, Smilova, M D, Solmesky, L J, Spencer, J, Strain-Damarell, C, Swamy, V, Tamir, H, Tennant, R, Thompson, W, Thompson, A, Tomasia, S, Tumber, A, Vakonakis, I, van Rij, R P, van Geel, L, Vaschetto, M, Vitner, E B, Voelz, V, Volkamer, A, von Delft, F, von Delft, A, Walsh, M, Ward, W, Weatherall, C, Weiss, S, White, K M, Wild, C F, Wittmann, M, Wright, N, Yahalom-Ronen, Y, Zaidmann, D, Zidane, H, Zitzmann, N, Costa, I G, Schneider, R K, Smeets, B & Kramann, R 2022, 'SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids', Cell Stem Cell, vol. 29, no. 2, pp. 217-231.e8. https://doi.org/10.1016/j.stem.2021.12.010en
dc.identifier.doi10.1016/j.stem.2021.12.010
dc.identifier.iss2en
dc.identifier.issn1934-5909
dc.identifier.otherRIS: urn:4BDB820E05FC430F97C51EC4BDF9AF1F
dc.identifier.otherORCID: /0000-0002-5522-4808/work/133393074
dc.identifier.urihttps://hdl.handle.net/2164/20478
dc.identifier.vol29en
dc.language.isoeng
dc.relation.ispartofCell Stem Cellen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectInfectious Diseasesen
dc.subjectNephrologyen
dc.subjectGeneral Medicineen
dc.subjectEuropean Research Councilen
dc.subjectERC-StG 677448en
dc.subjectERC-StG 757339en
dc.subjectH2020-ERC-2017-ADV-788982-COLMINen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleSARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoidsen
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Jansen_etal_CSC_SARS_CoV_2_Infects_The_VoR.pdf
Size:
158.69 KB
Format:
Adobe Portable Document Format
Download

Collections

All research