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A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

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dc.contributor.authorAbraham, Sabu
dc.contributor.authorScarcia, Margherita
dc.contributor.authorBagshaw, Richard D
dc.contributor.authorMcMahon, Kathryn
dc.contributor.authorGrant, Gary
dc.contributor.authorHarvey, Tracey
dc.contributor.authorYeo, Maggie
dc.contributor.authorEsteves, Filomena O G
dc.contributor.authorThygesen, Helene H
dc.contributor.authorJones, Pamela F
dc.contributor.authorSpeirs, Valerie
dc.contributor.authorHanby, Andrew M
dc.contributor.authorSelby, Peter J
dc.contributor.authorLorger, Mihaela
dc.contributor.authorDear, T Neil
dc.contributor.authorPawson, Tony
dc.contributor.authorMarshall, Christopher J
dc.contributor.authorMavria, Georgia
dc.date.accessioned2018-07-27T13:24:08Z
dc.date.available2018-07-27T13:24:08Z
dc.date.issued2015-07-01
dc.descriptionWe thank Hironori Katoh for EGFP DOCK4; Vijay Yajnik for flag-tagged DOCK4 and deletion mutants; Martin Schwartz for the DOCK9 expression construct; Len Stephens for RhoG expression construct; Jean-François Côté for GST–ELMO. We thank Janine Erler for advice on CA-IX staining and Kiran Kulkarni for discussions on DOCK9; Demelza Bird and Kris Wronski for the tumour experiments; Ben Woodman and staff at St James’ Biological Services for ES microinjections and animal husbandry; Biological Services Unit, ICR, for animal husbandry; Mike Shires for optimization of DOCK4 IHC; Anne Sanford and Rebecca Horsfall for technical assistance; Sean Lawler and other colleagues for commenting on the manuscript. The work was funded through project grant from Cancer Research UK (C107/A7631) awarded to C.J.M. and G.M.; project grant from Yorkshire Cancer Research (L357) and pilot grant from Breast Cancer Campaign (2012MaySP047) awarded to G.M. T.P. was supported by grants from the Ontario Research Fund GL2 program and CIHR (MOP-6849); and R.D.B. was supported by a CIHR fellowship. C.J.M. is a Gibb Life Fellow of Cancer Research UK.en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent4849380
dc.identifier129547290
dc.identifierccd5a453-2b19-4224-bd05-b70bd4bae5bc
dc.identifier26129894
dc.identifier84935140511
dc.identifier.citationAbraham, S, Scarcia, M, Bagshaw, R D, McMahon, K, Grant, G, Harvey, T, Yeo, M, Esteves, F O G, Thygesen, H H, Jones, P F, Speirs, V, Hanby, A M, Selby, P J, Lorger, M, Dear, T N, Pawson, T, Marshall, C J & Mavria, G 2015, 'A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis', Nature Communications, vol. 6, 7286. https://doi.org/10.1038/ncomms8286en
dc.identifier.doi10.1038/ncomms8286
dc.identifier.issn2041-1723
dc.identifier.otherPubMedCentral: PMC4507007
dc.identifier.otherORCID: /0000-0002-0602-4666/work/72631319
dc.identifier.urihttp://hdl.handle.net/2164/10817
dc.identifier.vol6en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAnimalsen
dc.subjectCytoskeletonen
dc.subjectGTPase-Activating Proteinsen
dc.subjectGuanine Nucleotide Exchange Factorsen
dc.subjectHuman Umbilical Vein Endothelial Cellsen
dc.subjectHumansen
dc.subjectMice, Inbred C57BLen
dc.subjectMice, Knockouten
dc.subjectNeovascularization, Pathologicen
dc.subjectNeovascularization, Physiologicen
dc.subjectPseudopodiaen
dc.subjectVascular Endothelial Growth Factor Aen
dc.subjectcdc42 GTP-Binding Proteinen
dc.subjectrho GTP-Binding Proteinsen
dc.subjectJournal Articleen
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectR Medicineen
dc.subjectCancer Research UKen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleA Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesisen
dc.typeJournal articleen

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