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Insulin resistance : Genetic associations with depression and cognition in population based cohorts

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dc.contributor.authorFrangou, Sophia
dc.contributor.authorShirali, Masoud
dc.contributor.authorAdams, Mark J
dc.contributor.authorHoward, David M
dc.contributor.authorGibson, Jude
dc.contributor.authorHall, Lynsey S
dc.contributor.authorSmith, Blair H
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorMurray, Alison D
dc.contributor.authorPorteous, David J
dc.contributor.authorHaley, Chris S
dc.contributor.authorDeary, Ian J
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2019-05-14T12:40:07Z
dc.date.available2019-05-14T12:40:07Z
dc.date.issued2019-06
dc.descriptionWe are grateful to the families who took part in GS:SFHS, general practitioners and the Scottish School of Primary Care for their help in recruitment, and the whole GS:SFHS team that includes academic researchers, clinic staff, laboratory technicians, clerical workers, IT staff, statisticians and research managers. The research reported here, and the genotyping of GS:SFHS samples was funded by the Wellcome Trust, (Wellcome Trust Strategic Award ‘STratifying Resilience and Depression Longitudinally’ (STRADL) Reference 104036/Z/14/Z) and by the Medical Research Council. SF acknowledges support from the National Institute of Mental Health, USA (R01MH113619; R01MH116147) and the consortium for Psychopathology and Allostatic load across the Life Span (PALS; https://www.pals-network.org) AMM acknowledges the financial support received from the Dr. Mortimer and Theresa Sackler Foundation. IJD and AMM are members of The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1). Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). Funding from the Biotechnology and Biological Sciences Research Council and Medical Research Council is gratefully acknowledged.en
dc.description.statusPeer revieweden
dc.format.extent7
dc.format.extent406109
dc.identifier143975177
dc.identifiercaddd7df-0438-43a8-9039-62d4c4c0a91d
dc.identifier30965038
dc.identifier85064199083
dc.identifier.citationFrangou, S, Shirali, M, Adams, M J, Howard, D M, Gibson, J, Hall, L S, Smith, B H, Padmanabhan, S, Murray, A D, Porteous, D J, Haley, C S, Deary, I J, Clarke, T-K & McIntosh, A M 2019, 'Insulin resistance : Genetic associations with depression and cognition in population based cohorts', Experimental Neurology, vol. 316, pp. 20-26. https://doi.org/10.1016/j.expneurol.2019.04.001en
dc.identifier.doi10.1016/j.expneurol.2019.04.001
dc.identifier.issn0014-4886
dc.identifier.otherMendeley: 493e021a-690e-334b-b9ae-03c1b5c1b4c4
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976592
dc.identifier.urihttp://hdl.handle.net/2164/12268
dc.identifier.urlhttp://www.mendeley.com/research/insulin-resistance-genetic-associations-depression-cognition-population-based-cohortsen
dc.identifier.vol316en
dc.language.isoeng
dc.relation.ispartofExperimental Neurologyen
dc.subjectInsulin resistanceen
dc.subjectMendelian randomizationen
dc.subjectPolygenic risk scoresen
dc.subjectGenetic associationen
dc.subjectDepressionen
dc.subjectCognitionen
dc.subjectR Medicine (General)en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleInsulin resistance : Genetic associations with depression and cognition in population based cohortsen
dc.typeJournal articleen

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