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Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy

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dc.contributor.authorTseng, Chih-Chung
dc.contributor.authorNoordali, Hannah
dc.contributor.authorSani, Monica
dc.contributor.authorMadhani, Melanie
dc.contributor.authorGrant, Denis M.
dc.contributor.authorFrenneaux, Michael
dc.contributor.authorZanda, Matteo
dc.contributor.authorGreig, Iain R.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2018-03-10T00:02:36Z
dc.date.available2018-03-10T00:02:36Z
dc.date.embargoedUntil2018-03-09
dc.date.issued2017-04-13
dc.descriptionWe thank Massimo Frigerio for technical support with the syntheses. We gratefully thank Signal Pharma for financial support and fellowship (C.C.T), and the EPSRC National Mass Spectrometry Service Centre (Swansea, UK) for performing HRMS analyses.en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent1025616
dc.identifier93926777
dc.identifier40c023a5-5b1d-4039-a2b1-9afc99fdf010
dc.identifier85017549463
dc.identifier.citationTseng, C-C, Noordali, H, Sani, M, Madhani, M, Grant, D M, Frenneaux, M, Zanda, M & Greig, I R 2017, 'Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy', Journal of Medicinal Chemistry, vol. 60, no. 7, pp. 2780-2789. https://doi.org/10.1021/acs.jmedchem.6b01592en
dc.identifier.doi10.1021/acs.jmedchem.6b01592
dc.identifier.iss7en
dc.identifier.issn0022-2623
dc.identifier.otherORCID: /0000-0003-0338-8664/work/35515839
dc.identifier.otherORCID: /0000-0003-0603-3383/work/65549954
dc.identifier.urihttp://hdl.handle.net/2164/10156
dc.identifier.vol60en
dc.language.isoeng
dc.relation.ispartofJournal of Medicinal Chemistryen
dc.subjectR Medicineen
dc.subjectEngineering and Physical Sciences Research Council (EPSRC)en
dc.subject.lccRen
dc.titleDevelopment of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacyen
dc.typeJournal articleen

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