Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators
| dc.contributor.author | De Mol, Eva | |
| dc.contributor.author | Szulc, Elzbieta | |
| dc.contributor.author | Di Sanza, Claudio | |
| dc.contributor.author | Martínez-Cristóbal, Paula | |
| dc.contributor.author | Bertoncini, Carlos W | |
| dc.contributor.author | Fenwick, R Bryn | |
| dc.contributor.author | Frigolé-Vivas, Marta | |
| dc.contributor.author | Masín, Marianela | |
| dc.contributor.author | Hunter, Irene | |
| dc.contributor.author | Buzón, Víctor | |
| dc.contributor.author | Brun-Heath, Isabelle | |
| dc.contributor.author | García, Jesús | |
| dc.contributor.author | De Fabritiis, Gianni | |
| dc.contributor.author | Estébanez-Perpiñá, Eva | |
| dc.contributor.author | McEwan, Iain J | |
| dc.contributor.author | Nebreda, Ángel R | |
| dc.contributor.author | Salvatella, Xavier | |
| dc.contributor.institution | University of Aberdeen.Applied Medicine | en |
| dc.contributor.institution | University of Aberdeen.Medical Sciences | en |
| dc.date.accessioned | 2019-01-02T00:05:32Z | |
| dc.date.available | 2019-01-02T00:05:32Z | |
| dc.date.issued | 2018-01-02 | |
| dc.description | Acknowledgments The authors thank Miquel Pons, Philipp Selenko, and Peter Wright for helpful discussions as well as Joan Miquel Valverde (IRB) and the ICTS NMR facility, managed by the scientific and technological centers of the University of Barcelona (CCiT UB), for their help in protein production and NMR. They also thank the IRB protein expression core facility for its assistance in cloning, the IRB advanced microscopy facility for assistance in immunofluorescence and PLA, and the IRB biostatistics and bioinformatics facility for assistance in the analysis of the gene reporter and PLA data. This work was supported by IRB, ICREA (X.S.), Obra Social “la Caixa” (E.D.M., E.S., and X.S.), MINECO (BIO2012-31043 and BIO2015-70092-R to X.S., BIO2014-53095-P to G.D.F.), Marató de TV3 (102030 to X.S. and 102031 to E.E.-P), the COFUND program of the European Commission (C.D.S.), the European Research Council (CONCERT, contract number 648201 to X.S.), the Ramón y Cajal program of MICINN (RYC-2011-07873 to C.W.B.), the Serra Hunter Program (E.E.-P.), AGAUR (SGR-2014-56RR14 to E.E.-P), and FEDER (G.D.F.). I.H. was supported by funding from the Chief Scientist's Office of the Scottish Government (ETM-258, ETM-382). IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from MINECO (Government of Spain). | en |
| dc.description.status | Peer reviewed | en |
| dc.format.extent | 8 | |
| dc.format.extent | 837375 | |
| dc.identifier | 113314005 | |
| dc.identifier | a0ecbb5f-411c-430c-bbab-36c79f49b78c | |
| dc.identifier | 29225078 | |
| dc.identifier | 85039843215 | |
| dc.identifier.citation | De Mol, E, Szulc, E, Di Sanza, C, Martínez-Cristóbal, P, Bertoncini, C W, Fenwick, R B, Frigolé-Vivas, M, Masín, M, Hunter, I, Buzón, V, Brun-Heath, I, García, J, De Fabritiis, G, Estébanez-Perpiñá, E, McEwan, I J, Nebreda, Á R & Salvatella, X 2018, 'Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators', Structure, vol. 26, no. 1, pp. 145-152. https://doi.org/10.1016/j.str.2017.11.007 | en |
| dc.identifier.doi | 10.1016/j.str.2017.11.007 | |
| dc.identifier.iss | 1 | en |
| dc.identifier.issn | 0969-2126 | |
| dc.identifier.uri | http://hdl.handle.net/2164/11708 | |
| dc.identifier.vol | 26 | en |
| dc.language.iso | eng | |
| dc.relation.ispartof | Structure | en |
| dc.subject | SDG 3 - Good Health and Well-being | en |
| dc.subject | androgen receptor | en |
| dc.subject | castration-resistant prostate cancer | en |
| dc.subject | transcription | en |
| dc.subject | intrinsic disorder | en |
| dc.subject | protein-protein interactions | en |
| dc.subject | transcription factor IIF | en |
| dc.subject | protein phosphorylation | en |
| dc.subject | R Medicine | en |
| dc.subject.lcc | R | en |
| dc.title | Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators | en |
| dc.type | Journal article | en |