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Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

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dc.contributor.authorAlexandru-Crivac, Cristina N.
dc.contributor.authorUmeobika, Christian
dc.contributor.authorLeikoski, Niina
dc.contributor.authorJokela, Jouni
dc.contributor.authorRickaby, Kirstie A.
dc.contributor.authorGrilo, André M.
dc.contributor.authorSjö, Peter
dc.contributor.authorPlowright, Alleyn T.
dc.contributor.authorIdress, Mohannad
dc.contributor.authorSiebs, Eike
dc.contributor.authorNneoyi-Egbe, Ada
dc.contributor.authorWahlsten, Matti
dc.contributor.authorSivonen, Kaarina
dc.contributor.authorJaspars, Marcel
dc.contributor.authorTrembleau, Laurent
dc.contributor.authorFewer, David P
dc.contributor.authorHoussen , Wael E.
dc.contributor.institutionUniversity of Aberdeen.Natural & Computing Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2017-11-16T12:02:07Z
dc.date.available2017-11-16T12:02:07Z
dc.date.issued2017-10-04
dc.descriptionThis project was supported by grants from the ERC (no. 339367, MJ), BBSRC IBCatalyst (no. BB/M028526/1, MJ, WEH), BBSRC FoF (no. BB/M013669/1, MJ, WEH), IBioIC Exemplar (no. 2014-2-4, MJ, WEH), an AstraZeneca studentship (MJ, WEH, LT, KR), the Academy of Finland (no. 259505, DPF) and the SULSA leaders award (WEH). The authors like to thank the Aberdeen Proteomics Facility and the Aberdeen School of Natural and Computing Sciences MS Facility for LCMS analysis. Electronic supplementary information (ESI) available: Experimental section, Fig. S1–S60 and Tables S1–S3. See DOI: 10.1039/c7cc05913ben
dc.description.statusPeer revieweden
dc.format.extent4
dc.format.extent1605404
dc.identifier107951047
dc.identifier8e63de52-9777-4a05-aa93-c614843d58a8
dc.identifier85030237036
dc.identifier.citationAlexandru-Crivac, C N, Umeobika, C, Leikoski, N, Jokela, J, Rickaby, K A, Grilo, A M, Sjö, P, Plowright, A T, Idress, M, Siebs, E, Nneoyi-Egbe, A, Wahlsten, M, Sivonen, K, Jaspars, M, Trembleau, L, Fewer, D P & Houssen , W E 2017, 'Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants', Chemical Communications, vol. 53, no. 77, pp. 10656-10659. https://doi.org/10.1039/C7CC05913Ben
dc.identifier.doi10.1039/C7CC05913B
dc.identifier.iss77en
dc.identifier.issn1359-7345
dc.identifier.otherORCID: /0000-0001-6376-9077/work/72631833
dc.identifier.otherORCID: /0000-0002-2426-6028/work/163664560
dc.identifier.urihttp://hdl.handle.net/2164/9611
dc.identifier.vol53en
dc.language.isoeng
dc.relation.ispartofChemical Communicationsen
dc.subjectQD Chemistryen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/M028526/1en
dc.subjectBB/M013669/1en
dc.subjectEuropean Research Councilen
dc.subject339367en
dc.subject.lccQDen
dc.titleCyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinantsen
dc.typeJournal articleen

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