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The impact of hypoxia on B cells in COVID-19

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dc.contributor.authorKotagiri, Prasanti
dc.contributor.authorMescia, Federica
dc.contributor.authorHanson, Aimee L
dc.contributor.authorTurner, Lorinda
dc.contributor.authorBergamaschi, Laura
dc.contributor.authorPeñalver, Ana
dc.contributor.authorRichoz, Nathan
dc.contributor.authorMoore, Stephen D
dc.contributor.authorOrtmann, Brian M
dc.contributor.authorDunmore, Benjamin J
dc.contributor.authorMorgan, Michael D
dc.contributor.authorTuong, Zewen Kelvin
dc.contributor.authorGöttgens, Berthold
dc.contributor.authorToshner, Mark
dc.contributor.authorHess, Christoph
dc.contributor.authorMaxwell, Patrick H
dc.contributor.authorClatworthy, Menna R
dc.contributor.authorNathan, James A
dc.contributor.authorBradley, John R
dc.contributor.authorLyons, Paul A
dc.contributor.authorBurrows, Natalie
dc.contributor.authorSmith, Kenneth G C
dc.contributor.authorCambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) Covid BioResource Collaboration
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2023-05-01T13:05:01Z
dc.date.available2023-05-01T13:05:01Z
dc.date.issued2022-03-01
dc.descriptionAcknowledgements We thank the patients and Health Care Workers who took part in this study. We are grateful for financial support from CVC Capital Partners, the Evelyn Trust (20/75), Addenbrooke’s Charitable Trust (12/20A) and the UKRI/NIHR through the UK Coronavirus Immunology Consortium (UK-CIC). We acknowledge NIHR Cambridge BioResource Centre (Grant codes:RG85445 and RG94028), NIHR Cambridge Clinic Research Facility outreach team, relevant NHS Trusts and their staff, and the Wellcome Trust (no. 19710) for supporting murine studies. K.G.C.S. is the recipient of a Wellcome Investigator Award (200871/Z/16/Z); C.H. was funded by a Wellcome COVID-19 Rapid Response DCF and the Fondation Botnar. J.A.N is the recipient of a Wellcome Senior Clinical Research Fellowship (215477/Z/19/Z) and a Lister Institute Research Fellowship. NB and AP are supported by the Wellcome Trust, Senior Investigator Award to P.H.M, and the Rosetrees Trust. NR is supported by the NIHR Cambridge Biomedical Research Centre. Z.K.T. and M.R.C. are supported by a Medical Research Council Human Cell Atlas Research Grant (MR/S035842/1). M.R.C is supported by an NIHR Research Professorship (RP-2017-08-ST2-002). PK is the recipient of a Jacquot Research Entry Scholarship of the Royal Australasian College of Physicians Foundation. We thank the NIHR, NHS Blood and Transplant, and Health Data Research UK as part of the Digital Innovation Hub Programme, and the NIHR Cambridge Biomedical Research Centre Cell Phenotyping Hub, the CRUK Cambridge Institute cytometry core and the Cambridge NIHR BRC Stratified Medicine Core Laboratory NGS Hub.en
dc.description.statusPeer revieweden
dc.format.extent140189
dc.identifier221555697
dc.identifier89b25475-0109-43f4-870e-6ea305e2303c
dc.identifier35189575
dc.identifier85124898529
dc.identifier.citationKotagiri, P, Mescia, F, Hanson, A L, Turner, L, Bergamaschi, L, Peñalver, A, Richoz, N, Moore, S D, Ortmann, B M, Dunmore, B J, Morgan, M D, Tuong, Z K, Göttgens, B, Toshner, M, Hess, C, Maxwell, P H, Clatworthy, M R, Nathan, J A, Bradley, J R, Lyons, P A, Burrows, N, Smith, K G C & Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) Covid BioResource Collaboration 2022, 'The impact of hypoxia on B cells in COVID-19', EBioMedicine, vol. 77, 103878. https://doi.org/10.1016/j.ebiom.2022.103878en
dc.identifier.doi10.1016/j.ebiom.2022.103878
dc.identifier.issn2352-3964
dc.identifier.otherPubMedCentral: PMC8856886
dc.identifier.otherORCID: /0000-0003-0757-0711/work/141722666
dc.identifier.urihttps://hdl.handle.net/2164/20597
dc.identifier.vol77en
dc.language.isoeng
dc.relation.ispartofEBioMedicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAnimalsen
dc.subjectCOVID-19en
dc.subjectHumansen
dc.subjectHypoxiaen
dc.subjectMiceen
dc.subjectOxygenen
dc.subjectPneumoniaen
dc.subjectSARS-CoV-2en
dc.subjectB cellsen
dc.subjectLymphopeniaen
dc.subjectR Medicineen
dc.subjectInfectious Diseasesen
dc.subjectCell Biologyen
dc.subjectImmunologyen
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectRG85445en
dc.subjectRG94028en
dc.subjectRP-2017-08-ST2-002en
dc.subjectUK Research and Innovation (UKRI)en
dc.subjectWellcome Trusten
dc.subject19710en
dc.subject200871/Z/16/Zen
dc.subject215477/Z/19/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/S035842/1en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleThe impact of hypoxia on B cells in COVID-19en
dc.typeJournal articleen

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