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Cells of the human intestinal tract mapped across space and time

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dc.contributor.authorElmentaite, Rasa
dc.contributor.authorKumasaka, Natsuhiko
dc.contributor.authorRoberts, Kenny
dc.contributor.authorFleming, Aaron
dc.contributor.authorDann, Emma
dc.contributor.authorKing, Hamish W
dc.contributor.authorKleshchevnikov, Vitalii
dc.contributor.authorDabrowska, Monika
dc.contributor.authorPritchard, Sophie
dc.contributor.authorBolt, Liam
dc.contributor.authorVieira, Sara F
dc.contributor.authorMamanova, Lira
dc.contributor.authorHuang, Ni
dc.contributor.authorPerrone, Francesca
dc.contributor.authorGoh Kai'En, Issac
dc.contributor.authorLisgo, Steven N
dc.contributor.authorKatan, Matilda
dc.contributor.authorLeonard, Steven
dc.contributor.authorOliver, Thomas R W
dc.contributor.authorHook, C Elizabeth
dc.contributor.authorNayak, Komal
dc.contributor.authorCampos, Lia S
dc.contributor.authorDomínguez Conde, Cecilia
dc.contributor.authorStephenson, Emily
dc.contributor.authorEngelbert, Justin
dc.contributor.authorBotting, Rachel A
dc.contributor.authorPolanski, Krzysztof
dc.contributor.authorvan Dongen, Stijn
dc.contributor.authorPatel, Minal
dc.contributor.authorMorgan, Michael D
dc.contributor.authorMarioni, John C
dc.contributor.authorBayraktar, Omer Ali
dc.contributor.authorMeyer, Kerstin B
dc.contributor.authorHe, Xiaoling
dc.contributor.authorBarker, Roger A
dc.contributor.authorUhlig, Holm H
dc.contributor.authorMahbubani, Krishnaa T
dc.contributor.authorSaeb-Parsy, Kourosh
dc.contributor.authorZilbauer, Matthias
dc.contributor.authorClatworthy, Menna R
dc.contributor.authorHaniffa, Muzlifah
dc.contributor.authorJames, Kylie R
dc.contributor.authorTeichmann, Sarah A
dc.date.accessioned2023-02-14T14:58:01Z
dc.date.available2023-02-14T14:58:01Z
dc.date.issued2021-09-08
dc.descriptionAcknowledgements We acknowledge support from the Wellcome Sanger Cytometry Core Facility, Cellular Genetics Informatics team, Cellular Generation and Phenotyping (CGaP) and Core DNA Pipelines. This work was financially supported by the Wellcome Trust (W1T20694, S.A.T.; 203151/Z/16/Z, R. A. Barker.); the European Research Council (646794, ThDefine, S.A.T.); an MRC New Investigator Research Grant (MR/T001917/1, M.Z.); and a project grant from the Great Ormond Street Hospital Children’s Charity, Sparks (V4519, M.Z.). The human embryonic and fetal material was provided by the Joint MRC/Wellcome (MR/R006237/1) Human Developmental Biology Resource (https://www.hdbr.org/). K.R.J. holds a Non-Stipendiary Junior Research Fellowship from Christ’s College, University of Cambridge. M.R.C. is supported by a Medical Research Council Human Cell Atlas Research Grant (MR/S035842/1) and a Wellcome Trust Investigator Award (220268/Z/20/Z). H.W.K. is funded by a Sir Henry Wellcome Fellowship (213555/Z/18/Z). A.F. is funded by a Wellcome PhD Studentship (102163/B/13/Z). K.T.M. is funded by an award from the Chan Zuckerberg Initiative. H.H.U. is supported by the Oxford Biomedical Research Centre (BRC) and the The Leona M. and Harry B. Helmsley Charitable Trust. We thank A. Chakravarti and S. Chatterjee for their contribution to the analysis of the enteric nervous system. We also thank R. Lindeboom and C. Talavera-Lopez for support with epithelium and Visium analysis, respectively; C. Tudor, T. Li and O. Tarkowska for image processing and infrastructure support; A. Wilbrey-Clark and T. Porter for support with Visium library preparation; A. Ross and J. Park for access to and handling of fetal tissue; A. Hunter for assistance in protocol development; D. Fitzpatrick for discussion on developmental intestinal disorders; and J. Eliasova for the graphical images. We thank the tissue donors and their families, and the Cambridge Biorepository for Translational Medicine and Human Developmental Biology Resource, for access to human tissue. This publication is part of the Human Cell Atlas: https://www.humancellatlas.org/publications.en
dc.description.statusPeer revieweden
dc.format.extent6
dc.format.extent21961281
dc.identifier221556165
dc.identifier4416d7db-1043-4b23-8df0-ae2d16722283
dc.identifier34497389
dc.identifier85114616944
dc.identifier.citationElmentaite, R, Kumasaka, N, Roberts, K, Fleming, A, Dann, E, King, H W, Kleshchevnikov, V, Dabrowska, M, Pritchard, S, Bolt, L, Vieira, S F, Mamanova, L, Huang, N, Perrone, F, Goh Kai'En, I, Lisgo, S N, Katan, M, Leonard, S, Oliver, T R W, Hook, C E, Nayak, K, Campos, L S, Domínguez Conde, C, Stephenson, E, Engelbert, J, Botting, R A, Polanski, K, van Dongen, S, Patel, M, Morgan, M D, Marioni, J C, Bayraktar, O A, Meyer, K B, He, X, Barker, R A, Uhlig, H H, Mahbubani, K T, Saeb-Parsy, K, Zilbauer, M, Clatworthy, M R, Haniffa, M, James, K R & Teichmann, S A 2021, 'Cells of the human intestinal tract mapped across space and time', Nature, vol. 597, no. 7875, pp. 250-255. https://doi.org/10.1038/s41586-021-03852-1en
dc.identifier.doi10.1038/s41586-021-03852-1
dc.identifier.iss7875en
dc.identifier.issn0028-0836
dc.identifier.otherPubMedCentral: PMC8426186
dc.identifier.otherORCID: /0000-0003-0757-0711/work/128823890
dc.identifier.urihttps://hdl.handle.net/2164/20033
dc.identifier.vol597en
dc.language.isoeng
dc.relation.ispartofNatureen
dc.subjectNo substantive connection to the University of Aberdeenen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAdulten
dc.subjectAgingen
dc.subjectAnimalsen
dc.subjectChilden
dc.subjectCrohn Disease/pathologyen
dc.subjectDatasets as Topicen
dc.subjectEnteric Nervous System/anatomy & histologyen
dc.subjectEpithelial Cells/cytologyen
dc.subjectFemaleen
dc.subjectFetus/anatomy & histologyen
dc.subjectHealthen
dc.subjectHumansen
dc.subjectIntestines/cytologyen
dc.subjectLymph Nodes/cytologyen
dc.subjectMiceen
dc.subjectMice, Inbred C57BLen
dc.subjectOrganogenesisen
dc.subjectReceptors, IgG/metabolismen
dc.subjectSignal Transductionen
dc.subjectSpatio-Temporal Analysisen
dc.subjectTime Factorsen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subjectW1T20694en
dc.subject203151/Z/16/Z,en
dc.subject220268/Z/20/Zen
dc.subject213555/Z/18/Zen
dc.subject102163/B/13/Zen
dc.subjectEuropean Research Councilen
dc.subject646794en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/T001917/1, M.Zen
dc.subjectMR/R006237/1en
dc.subjectMR/S035842/1en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleCells of the human intestinal tract mapped across space and timeen
dc.typeJournal articleen

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