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Low-dose 2-Deoxy Glucose Stabilises Tolerogenic Dendritic Cells and Generates Potent in vivo Immunosuppressive Effects

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dc.contributor.authorChristofi, Maria
dc.contributor.authorLe Sommer, S.
dc.contributor.authorMoelzer, Christine
dc.contributor.authorKlaska, I. P.
dc.contributor.authorKuffova, L
dc.contributor.authorForrester, J V
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2021-04-08T16:33:02Z
dc.date.available2021-04-08T16:33:02Z
dc.date.issued2021-03
dc.descriptionOpen Access via Springer Compact Agreement University of Aberdeen Development Trust Grant number RG14251, RG12663 Acknowledgements: We thank the University of Aberdeen Iain Fraser Flow Cytometry core facility, and the University of Aberdeen Histology and Microscopy core facility for processing of histology slides. The authors thank University of Aberdeen Medical Research Facility for technical assistance with in vivo experiments. We thank Dr. Tian Yu, Dr. Yi-Hsia Liu, Mrs Rosemary Fordyce, and Mrs Elizabeth Muckersie for technical assistance with in vivo and in vitro experiments. Funding: This work was supported by funds from the University of Aberdeen Development Trust Grants RG14251 and RG12663. Maria Christof was the recipient of a University of Aberdeen PhD Studentship. Samantha Le Sommer was funded by a Wellcome Trust ISSF Postdoctoral Fellowship.en
dc.description.statusPeer revieweden
dc.format.extent20
dc.format.extent4881168
dc.identifier177286011
dc.identifier9b705f08-761c-4880-b10d-a6b6b60e917b
dc.identifier85092688822
dc.identifier000581039800001
dc.identifier33074350
dc.identifier.citationChristofi, M, Le Sommer, S, Moelzer, C, Klaska, I P, Kuffova, L & Forrester, J V 2021, 'Low-dose 2-Deoxy Glucose Stabilises Tolerogenic Dendritic Cells and Generates Potent in vivo Immunosuppressive Effects', Cellular and Molecular Life Sciences, vol. 78, no. 6, pp. 2857-2876. https://doi.org/10.1007/s00018-020-03672-yen
dc.identifier.doi10.1007/s00018-020-03672-y
dc.identifier.iss6en
dc.identifier.issn1420-682X
dc.identifier.otherORCID: /0000-0002-8015-7774/work/83311010
dc.identifier.otherORCID: /0000-0003-3301-7397/work/83311209
dc.identifier.urihttps://hdl.handle.net/2164/16206
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85092688822&partnerID=8YFLogxKen
dc.identifier.vol78en
dc.language.isoeng
dc.relation.ispartofCellular and Molecular Life Sciencesen
dc.subjectAutoimmunityen
dc.subjectCell therapyen
dc.subjectMetabolic programmingen
dc.subjectToleranceen
dc.subjectZbtb46en
dc.subjectRHEUMATOID-ARTHRITISen
dc.subjectACTIVATIONen
dc.subjectHOMEOSTASISen
dc.subjectMACROPHAGEen
dc.subjectEXPERIMENTAL AUTOIMMUNE UVEORETINITISen
dc.subjectSIRP-ALPHAen
dc.subjectINHIBITIONen
dc.subjectIMMUNOTHERAPYen
dc.subjectSTEADY-STATEen
dc.subjectT-CELLSen
dc.subjectR Medicineen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectMolecular Medicineen
dc.subjectMolecular Biologyen
dc.subjectCell Biologyen
dc.subjectPharmacologyen
dc.subjectOtheren
dc.subjectRG12663en
dc.subjectRG14251en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleLow-dose 2-Deoxy Glucose Stabilises Tolerogenic Dendritic Cells and Generates Potent in vivo Immunosuppressive Effectsen
dc.typeJournal articleen

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