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Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.

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dc.contributor.authorWoodley, Keith
dc.contributor.authorDillingh, LS
dc.contributor.authorGiotopoulos, George
dc.contributor.authorMadrigal, Pedro
dc.contributor.authorRattigan, KM
dc.contributor.authorPhilippe, Céline
dc.contributor.authorDembitz, Vilma
dc.contributor.authorMagee, AMS
dc.contributor.authorAsby, R
dc.contributor.authorvan de Lagemaat, Louie N
dc.contributor.authorMapperley, Christopher
dc.contributor.authorJames, SC
dc.contributor.authorPrehn, JHM
dc.contributor.authorTzelepis, Konstantinos
dc.contributor.authorRouault-Pierre, Kevin
dc.contributor.authorVassiliou, George
dc.contributor.authorKranc, Kamil
dc.contributor.authorHelgason, G Vignir
dc.contributor.authorHuntly, BJP
dc.contributor.authorGallipoli, Paolo
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2023-09-14T10:37:00Z
dc.date.available2023-09-14T10:37:00Z
dc.date.issued2023-04-14
dc.descriptionAcknowledgements We wish to thank the Barts Cancer Institute tissue bank for sample collection and processing. This research was supported by the BCI Flow cytometry facility (CRUK Core Award C16420/A18066). This work was supported by the Wellcome Trust (PG, 109967/Z/15/Z), the American Society of Haematology (PG, Global Research Award) and Cancer Research UK (PG, Advanced Clinician Scientist fellowship, C57799/A27964). K.R-P. was supported by the Academy of Medical Sciences (SBF004\1099) J.H.M.P. was supported by a research grant from Science Foundation Ireland (SFI) under Grant Number 16/RC/3948 and co-funded under the European Regional Development Fund and by FutureNeuro industry partners. K.T. was funded by Wellcome Trust (Grant References: RG94424, RG83195, G106133), UKRI Medical Research Council (RG83195) and Leukaemia UK (G108148).en
dc.description.statusPeer revieweden
dc.format.extent19
dc.format.extent1565762
dc.identifier272251574
dc.identifier62dea054-7347-4465-abce-c8ba45072461
dc.identifier37059720
dc.identifierPMC10104861
dc.identifier85152580097
dc.identifier.citationWoodley, K, Dillingh, LS, Giotopoulos, G, Madrigal, P, Rattigan, KM, Philippe, C, Dembitz, V, Magee, AMS, Asby, R, van de Lagemaat, L N, Mapperley, C, James, SC, Prehn, JHM, Tzelepis, K, Rouault-Pierre, K, Vassiliou, G, Kranc, K, Helgason, G V, Huntly, BJP & Gallipoli, P 2023, 'Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.', Nature Communications, vol. 14, 2132. https://doi.org/10.1038/s41467-023-37652-0en
dc.identifier.doi10.1038/s41467-023-37652-0
dc.identifier.issn2041-1723
dc.identifier.otherORCID: /0000-0002-2947-1557/work/140168203
dc.identifier.urihttps://hdl.handle.net/2164/21669
dc.identifier.urlhttps://europepmc.org/articles/PMC10104861en
dc.identifier.vol14en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectcancer metabolismen
dc.subjectcancer therapeutic resistanceen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subjectPG, 109967/Z/15/Zen
dc.subjectRG94424en
dc.subjectRG83195en
dc.subjectCancer Research UKen
dc.subjectC16420/A18066en
dc.subjectC57799/A27964en
dc.subjectG106133en
dc.subjectMedical Research Council (MRC)en
dc.subjectRG83195en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleMannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.en
dc.typeJournal articleen

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