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IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

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dc.contributor.authorDambuza, Ivy M
dc.contributor.authorHe, Chang
dc.contributor.authorChoi, Jin Kyeong
dc.contributor.authorYu, Cheng-Rong
dc.contributor.authorWang, Renxi
dc.contributor.authorMattapallil, Mary J
dc.contributor.authorWingfield, Paul T
dc.contributor.authorCaspi, Rachel R
dc.contributor.authorEgwuagu, Charles E
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2018-11-20T15:10:07Z
dc.date.available2018-11-20T15:10:07Z
dc.date.issued2017-09-28
dc.descriptionWe thank Dr. Haohua Qian and Yichao Li (Visual function core, NEI, NIH) for technical assistance with OCT; Phyllis Silver (NEI, NIH) for EAU scoring of the eyes; Rashid Mahdi. M.J.M. for technical assistance with western blot analyses and Rafael Villasmil (NEI FLOW Cytometry Core facility) for assistance with FACS analysis.en
dc.description.statusPeer revieweden
dc.format.extent2437176
dc.identifier140644626
dc.identifiercd8f5c28-3d67-4852-ad0a-43f2b0e772c0
dc.identifier28959012
dc.identifier85030101852
dc.identifier.citationDambuza, I M, He, C, Choi, J K, Yu, C-R, Wang, R, Mattapallil, M J, Wingfield, P T, Caspi, R R & Egwuagu, C E 2017, 'IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease', Nature Communications, vol. 8, 719. https://doi.org/10.1038/s41467-017-00838-4en
dc.identifier.doi10.1038/s41467-017-00838-4
dc.identifier.issn2041-1723
dc.identifier.otherPubMedCentral: PMC5620058
dc.identifier.urihttp://hdl.handle.net/2164/11477
dc.identifier.vol8en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectAnimalsen
dc.subjectAutoimmune Diseases/immunologyen
dc.subjectB-Lymphocytes, Regulatory/metabolismen
dc.subjectCell Proliferationen
dc.subjectImmunosuppressionen
dc.subjectInterleukin-10/metabolismen
dc.subjectInterleukin-12 Receptor beta 2 Subunit/metabolismen
dc.subjectInterleukin-12 Subunit p35/metabolismen
dc.subjectMice, Inbred C57BLen
dc.subjectMice, Knockouten
dc.subjectProtein Multimerizationen
dc.subjectT-Lymphocytes, Regulatory/immunologyen
dc.subjectTh17 Cells/immunologyen
dc.subjectUveitis/immunologyen
dc.subjectQR180 Immunologyen
dc.subject.lccQR180en
dc.titleIL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune diseaseen
dc.typeJournal articleen

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