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In vivo modulation of cervicovaginal drug transporters and tissue distribution by film-released tenofovir and darunavir for topical prevention of HIV-1

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dc.contributor.authorHijazi, Karolin
dc.contributor.authorIannelli, Francesco
dc.contributor.authorCuppone, Anna Maria
dc.contributor.authorDesjardins, Delphine
dc.contributor.authorCaldwell, Anna
dc.contributor.authorDereuddre-Bosquet, Nathalie
dc.contributor.authorScala, Carlo
dc.contributor.authorSmith, Kieron A
dc.contributor.authorMukhopadhya, Indrani
dc.contributor.authorFrank, Bruce
dc.contributor.authorGwozdz, Garry
dc.contributor.authorSantoro, Francesco
dc.contributor.authorLe Grand, Roger
dc.contributor.authorPozzi, Gianni
dc.contributor.authorKelly, Charles G
dc.contributor.institutionUniversity of Aberdeen.Dental Educationen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2021-02-04T00:08:12Z
dc.date.available2021-02-04T00:08:12Z
dc.date.embargoedUntil2021-02-04
dc.date.issued2020-03-02
dc.descriptionWe thank Gilead Science for provision of tenofovir and Janssen R&D Ireland for provision of darunavir. We thank members of the MOTIF consortium for useful discussions and exchange of ideas during the course of this study. We thank the technical staff of IDMIT, the animal care and veterinary staff at CEA, Fontenay-aux-Roses, France. Funding: this work was supported by the European Union's Seventh Programme for research, technological development and demonstration under grant agreement No 305316 as part of the MOTIF (Microbicides Formulation Through Innovative Formulation for Vaginal and Rectal Delivery) project. It has also the support of the “Investissements d’Avenir” French government program managed by the Agence Nationale de la Recherche under ANR-11-INBS-0008 funding for the Infectious Disease Models and Innovative Therapies (IDMIT, Fontenay-aux-Roses, France) infrastructure, and ANR-10-EQPX-02-01 funding for the FlowCyTech facility (IDMIT, Fontenay-aux-Roses, France).en
dc.description.statusPeer revieweden
dc.format.extent13
dc.format.extent511202
dc.identifier156647375
dc.identifierdca6dff7-1fa5-452f-85c4-61a18e849990
dc.identifier85080093342
dc.identifier000518088600013
dc.identifier.citationHijazi, K, Iannelli, F, Cuppone, A M, Desjardins, D, Caldwell, A, Dereuddre-Bosquet, N, Scala, C, Smith, K A, Mukhopadhya, I, Frank, B, Gwozdz, G, Santoro, F, Le Grand, R, Pozzi, G & Kelly, C G 2020, 'In vivo modulation of cervicovaginal drug transporters and tissue distribution by film-released tenofovir and darunavir for topical prevention of HIV-1', Molecular Pharmaceutics, vol. 17, no. 3, pp. 852-864. https://doi.org/10.1021/acs.molpharmaceut.9b01121en
dc.identifier.doi10.1021/acs.molpharmaceut.9b01121
dc.identifier.iss3en
dc.identifier.issn1543-8384
dc.identifier.otherORCID: /0000-0003-2577-518X/work/142142585
dc.identifier.urihttps://hdl.handle.net/2164/15775
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85080093342&partnerID=8YFLogxKen
dc.identifier.vol17en
dc.language.isoeng
dc.relation.ispartofMolecular Pharmaceuticsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectMultidrug resistance associated proteinen
dc.subjecttenofoviren
dc.subjectdarunaviren
dc.subjectmicrobicidesen
dc.subjectvaginaen
dc.subjectmacaquesen
dc.subjectmultidrug resistance associated proteinen
dc.subjectCELLSen
dc.subjectPROTEASE INHIBITORSen
dc.subjectP-GLYCOPROTEINen
dc.subjectVAGINAL RINGSen
dc.subjectEFFLUX TRANSPORTERSen
dc.subjectREVERSE-TRANSCRIPTASE INHIBITORSen
dc.subjectDISOPROXIL FUMARATEen
dc.subjectINTRACELLULAR ACCUMULATIONen
dc.subjectMULTIDRUG-RESISTANCEen
dc.subjectEXPRESSIONen
dc.subjectR Medicineen
dc.subjectDrug Discoveryen
dc.subjectMolecular Medicineen
dc.subjectPharmaceutical Scienceen
dc.subjectEuropean Commissionen
dc.subject305316en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleIn vivo modulation of cervicovaginal drug transporters and tissue distribution by film-released tenofovir and darunavir for topical prevention of HIV-1en
dc.typeJournal articleen

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