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Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

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dc.contributor.authorKleeman, Sam O.
dc.contributor.authorKoelzer, Viktor H.
dc.contributor.authorJones, Helen J.S.
dc.contributor.authorVazquez, Ester Gil
dc.contributor.authorDavis, Hayley
dc.contributor.authorEast, James E.
dc.contributor.authorArnold, Roland
dc.contributor.authorKoppens, Martijn A.J.
dc.contributor.authorBlake, Andrew
dc.contributor.authorDomingo, Enric
dc.contributor.authorCunningham, Chris
dc.contributor.authorBeggs, Andrew D.
dc.contributor.authorPestinger, Valerie
dc.contributor.authorLoughrey, Maurice B.
dc.contributor.authorWang, Lai-Mun
dc.contributor.authorLannagan, Tamsin R.M.
dc.contributor.authorWoods, Susan L.
dc.contributor.authorWorthley, Daniel
dc.contributor.authorThe S:CORT Consortium
dc.contributor.authorTomlinson, Ian
dc.contributor.authorDunne, Philip D.
dc.contributor.authorMaughan, Timothy
dc.contributor.authorLeedham, Simon J.
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2020-05-12T14:55:00Z
dc.date.available2020-05-12T14:55:00Z
dc.date.issued2019-09-28
dc.descriptionAcknowledgments The authors would like to thank Graeme Murray for provision of the rectal cancer biopsies under licence from the Grampian biorepository, to Matt Seymour for use of the FOCUS trial samples and to the MRC FOCUS trial management group. Funding: This work was supported by Wellcome Trust Senior Clinical Research Fellowship (206314/Z/17/Z) and Worldwide Cancer Research grant (16-0042) to SJL, the Stratification in Colorectal Cancer (S:CORT) Consortium, which is funded by the Medical Research Council and Cancer Research UK and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre. VHK was funded by the Swiss National Science Foundation (P2SKP3_168322/1 and P2SKP3_168322/2). HJSJ was supported by a Bowel Disease Research Foundation (BDRF) research grant. ADB is funded by a Cancer Research UK Advanced Clinician Scientist award (C31641/A23923) and the Wellcome Trust (102732/Z/13/Z). TRML, SLW and DW supported by the NHMRC, Beat Cancer SA & Cure Cancer Australia. JEE was funded by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC). Core funding to the Wellcome Trust Centre for Human Genetics was provided by the Wellcome Trust (090532/Z/09/Z). Data availability statement: Data relating to transcriptome profiling of relevant genes in polyps cohort and validation cohorts A/B are available online (https://www.s-cort.org/exploiting-differential-wnt). All other data relevant to the study are referenced, included in the article or uploaded as supplementary information.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent15168043
dc.identifier148188113
dc.identifierc7783807-5f63-40ee-976a-654a260acb60
dc.identifier85084379743
dc.identifier000538121200020
dc.identifier.citationKleeman, S O, Koelzer, V H, Jones, H J S, Vazquez, E G, Davis, H, East, J E, Arnold, R, Koppens, M A J, Blake, A, Domingo, E, Cunningham, C, Beggs, A D, Pestinger, V, Loughrey, M B, Wang, L-M, Lannagan, T R M, Woods, S L, Worthley, D, The S:CORT Consortium, Tomlinson, I, Dunne, P D, Maughan, T & Leedham, S J 2019, 'Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification', Gut, vol. 69, pp. 1092-1103. https://doi.org/10.1136/gutjnl-2019-319126en
dc.identifier.doi10.1136/gutjnl-2019-319126
dc.identifier.issn0017-5749
dc.identifier.otherRIS: urn:FACD63D229080594612105E9F5EFF426
dc.identifier.otherORCID: /0000-0003-3981-2420/work/76973667
dc.identifier.otherunpaywall: 10.1136/gutjnl-2019-319126
dc.identifier.urihttps://hdl.handle.net/2164/14310
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85084379743&partnerID=8YFLogxKen
dc.identifier.vol69en
dc.language.isoeng
dc.relation.ispartofGuten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAXIN2en
dc.subjectcolorectal canceren
dc.subjectmolecular biomarkeren
dc.subjectstratificationen
dc.subjectWnt signallingen
dc.subjectRNF43en
dc.subjectCOLONen
dc.subjectFUSIONSen
dc.subjectMUTATIONSen
dc.subjectTUMORSen
dc.subjectR Medicine (General)en
dc.subjectGastroenterologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectCancer Research UKen
dc.subjectC31641/A23923en
dc.subjectOtheren
dc.subject16-0042en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectWellcome Trusten
dc.subject206314/Z/17/Zen
dc.subject102732/Z/13/Zen
dc.subject090532/Z/09/Zen
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleExploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratificationen
dc.typeJournal articleen

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