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Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals

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dc.contributor.authorShi, Liu
dc.contributor.authorBuchanan, Colin R
dc.contributor.authorCox, Simon R.
dc.contributor.authorHillary, Robert F.
dc.contributor.authorMarioni, Riccardo E
dc.contributor.authorCampbell, Archie
dc.contributor.authorHayward, Caroline
dc.contributor.authorStolicyn, Aleks
dc.contributor.authorWhalley, Heather C.
dc.contributor.authorHarris, Matthew A.
dc.contributor.authorWaymont, Jennifer M.J.
dc.contributor.authorWaiter, Gordon
dc.contributor.authorBackhouse, Ellen V.
dc.contributor.authorWardlaw, Joanna M.
dc.contributor.authorSteele, Douglas
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorLovestone, Simon
dc.contributor.authorBuckley, Noel
dc.contributor.authorNevado-Holgado, Alejo J.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2022-02-01T10:15:02Z
dc.date.available2022-02-01T10:15:02Z
dc.date.issued2021-09-27
dc.descriptionThis project was funded by DPUK through MRC (grant no. MR/L023784/2) and the UK Medical Research Council Award to the University of Oxford (grant no. MC_PC_17215). L.S is funded by the Virtual Brain Cloud from European comission (grant no. H2020-SC1-DTH-2018-1). C.R.B is funded by National Institutes of Health (NIH) research grant R01AG054628. S.R.C is funded by National Institutes of Health (NIH) research grant (R01AG054628), Medical Research Council (MR/R024065/1), Age UK and Economic and Social Research Council. R.E.M. was supported by Alzheimer's Research UK major project grant ARUKPG2017B-10. C.H was supported by an MRC Human Genetics Unit programme grant “Quantitative traits in health and disease” (U.MC_UU_00007/10). H.C.W received funding from Wellcome Trust. J.W is funded by TauRx pharmaceuticals Ltd and received Educational grant from Biogen paid to Alzheimer Scotland/Brain Health Scotland. G.W received GRAMPIAN UNIVERSITY HOSPITALS NHS TRUST, Scottish Government—Chief Scientist Office, ROLAND SUTTON ACADEMIC TRUST, Medical Research Scotland, Sutton Academic Trust and ROLAND SUTTON ACADEMIC TRUST. J.M.W received Wellcome Trust Strategic Award, MRC UK Dementia Research Institute and MRC project grants, Fondation Leducq, Stroke Association, British Heart Foundation, Alzheimer Society, and the European Union H2020 PHC-03-15 SVDs@Target grant (666881). D.S received MRC (MR/S010351/1), MRC (MR/W002388/1) and MRC (MR/W002566/1). A.M is supported by the Wellcome Trust (104036/Z/14/Z, 216767/Z/19/Z, 220857/Z/20/Z) and UKRI MRC (MC_PC_17209, MR/S035818/1). This work is part of a project that has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 847776. In addition, A.M has received grant support from The Sackler Trust, outside of the work presented. N.B received grant to institution from GSK as part of GSK/Oxford FxG initiative. A.N.H received John Black Charitable Fund-Rosetrees, H2020 funding from European Comission-Project Virtual Brain Cloud, AI for the Discovery of new therapies in Parkinson's (A2926), Rising Start Initiative—stage 2, Brain-Gut Microbiome (Call: PAR-18-296; Award ID: 1U19AG063744-01), Gut-liver-brain biochemical axis in Alzheimer's disease (5RF1AG057452-01), Virtual Brain Cloud (Call: H2020-SC1-DTH- 2018-1; Grant agreement ID: 826421). Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006) and is currently supported by the Wellcome Trust (216767/Z/19/Z). Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility, University of Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” [STRADL] Reference 104036/Z/14/Z). We are grateful to all the families who took part; the general practitioners and the Scottish School of Primary Care for their help in recruiting them; and the whole Generation Scotland team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, health-care assistants, and nurses.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent1935607
dc.identifier212589190
dc.identifier2511687c-04b5-47a3-acba-9433473a3c02
dc.identifier85123174318
dc.identifier.citationShi, L, Buchanan, C R, Cox, S R, Hillary, R F, Marioni, R E, Campbell, A, Hayward, C, Stolicyn, A, Whalley, H C, Harris, M A, Waymont, J M J, Waiter, G, Backhouse, E V, Wardlaw, J M, Steele, D, McIntosh, A M, Lovestone, S, Buckley, N & Nevado-Holgado, A J 2021, 'Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 13, no. 1, e12240. https://doi.org/10.1002/dad2.12240en
dc.identifier.doi10.1002/dad2.12240
dc.identifier.issn2352-8729
dc.identifier.otherORCID: /0000-0002-5313-9845/work/107490004
dc.identifier.otherORCID: /0000-0001-6688-7132/work/194700921
dc.identifier.urihttps://hdl.handle.net/2164/18009
dc.language.isoeng
dc.relation.ispartofAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoringen
dc.subjectmeditationen
dc.subjectneurodegenerationen
dc.subjectplasma proteomicsen
dc.subjectvascular damageen
dc.subjectsex related differenceen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/L023784/2en
dc.subjectMC_PC_17215en
dc.subjectMR/R024065/1en
dc.subjectMR/S010351/1en
dc.subjectMR/S035818/1en
dc.subjectMR/W002566/1en
dc.subjectMR/W002388/1en
dc.subjectEuropean Commissionen
dc.subjectH2020-SC1-DTH-2018-1en
dc.subjectH2020 PHC-03-15en
dc.subject847776en
dc.subjectAlzheimers Research UKen
dc.subjectARUKPG2017B-10en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subject216767/Z/19/Zen
dc.subject220857/Z/20/Zen
dc.subjectScottish Funding Councilen
dc.subjectHR03006en
dc.subjectOtheren
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleIdentification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individualsen
dc.typeJournal articleen

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