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A GWAS meta-analysis of alpha angle suggests cam-type morphology may be a specific feature of hip osteoarthritis in older adults

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dc.contributor.authorFaber, Benjamin G
dc.contributor.authorFrysz, Monika
dc.contributor.authorHartley, April E.
dc.contributor.authorEbsim, Raja
dc.contributor.authorBoer, Cindy G.
dc.contributor.authorSaunders, Fiona
dc.contributor.authorGregory, Jenny
dc.contributor.authorAspden, Richard Malcolm
dc.contributor.authorHarvey, Nicholas C
dc.contributor.authorSoutham, Lorraine
dc.contributor.authorGiles, William
dc.contributor.authorLe Maitre, Christine L.
dc.contributor.authorWilkinson, J. Mark
dc.contributor.authorvan Meurs, Joyce B.J.
dc.contributor.authorZeggini, Eleftheria
dc.contributor.authorCootes, Timothy
dc.contributor.authorLindner, Claudia
dc.contributor.authorKemp, John P.
dc.contributor.authorSmith, George Davey
dc.contributor.authorTobias, Jonathan H.
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)en
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2023-07-20T13:28:01Z
dc.date.available2023-07-20T13:28:01Z
dc.date.issued2023-06
dc.descriptionAcknowledgements The authors would like to thank the Musculoskeletal Research Unit patient and public involvement group at the University of Bristol for their input into planning our research and Dr Martin Williams, Consultant Musculoskeletal Radiologist North Bristol NHS Trust, who provided substantial training and expertise for this study. This work has been conducted using the UK Biobank resource (application number 17295). The authors would like to thank the study participants, the staff from the Rotterdam Study and the participating general practitioners and pharmacists. The generation and management of GWAS genotype data for the Rotterdam Study (RSI, RSII, RSIII) was executed by the Human Genotyping Facility of the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. The authors would like to thank Pascal Arp, Mila Jhamai, Marijn Verkerk, Lizbeth Herrera and Marjolein Peters, MSc, and Carolina Medina-Gomez, MSc, for their help in creating the GWAS database, and Linda Broer PhD, for the creation of the imputed data. Mathijs Versteeg for creating the alpha angle data. Funding and grant award information: BGF is supported by a Medical Research Council (MRC) clinical research training fellowship (MR/S021280/1). RE, MF, FS are supported, and this work is funded by a Wellcome Trust collaborative award (reference number 209233). CL is funded by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (223267/Z/21/Z). This research was funded in whole, or in part, by the Wellcome Trust [Grant numbers 080280/Z/06/Z, 20378/Z/16/Z, 223267/Z/21/Z]. For the purpose of open access, the authors have applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. NCH acknowledges support from the MRC and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton. BGF, MF, The genetic architecture of cam morphology AEH, GDS, JHT work in the MRC Integrative Epidemiology Unit at the University of Bristol, which is supported by the MRC (MC_UU_00011/1). JPK is funded by a National Health and Medical Research Council (Australia) Investigator grant (GNT1177938)en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent845851
dc.identifier226261924
dc.identifier5f40ac99-77dc-42b1-893a-2f44c7b056c1
dc.identifier36662418
dc.identifier85152126186
dc.identifier.citationFaber, B G, Frysz, M, Hartley, A E, Ebsim, R, Boer, C G, Saunders, F, Gregory, J, Aspden, R M, Harvey, N C, Southam, L, Giles, W, Le Maitre, C L, Wilkinson, J M, van Meurs, J B J, Zeggini, E, Cootes, T, Lindner, C, Kemp, J P, Smith, G D & Tobias, J H 2023, 'A GWAS meta-analysis of alpha angle suggests cam-type morphology may be a specific feature of hip osteoarthritis in older adults', Arthritis & Rheumatology, vol. 75, no. 6, pp. 900-909. https://doi.org/10.1002/art.42451en
dc.identifier.doi10.1002/art.42451
dc.identifier.iss6en
dc.identifier.issn2326-5191
dc.identifier.otherORCID: /0000-0001-7130-6777/work/127818115
dc.identifier.urihttps://hdl.handle.net/2164/21268
dc.identifier.vol75en
dc.language.isoeng
dc.relation.ispartofArthritis & Rheumatologyen
dc.subjectGenome Wide Association Studies,en
dc.subjectosteoarthritisen
dc.subjectfemoro-acetabular impingementen
dc.subjectimagingen
dc.subjectalpha angleen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/S021280/1en
dc.subjectMC_UU_00011/1en
dc.subjectWellcome Trusten
dc.subject223267/Z/21/Zen
dc.subject080280/Z/06/Zen
dc.subject20378/Z/16/Zen
dc.subject209233en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleA GWAS meta-analysis of alpha angle suggests cam-type morphology may be a specific feature of hip osteoarthritis in older adultsen
dc.typeJournal articleen

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