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Do regional brain volumes and major depressive disorder share genetic architecture? : A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766)

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dc.contributor.authorWigmore, E. M.
dc.contributor.authorClarke, T-K
dc.contributor.authorHoward, D. M.
dc.contributor.authorAdams, M. J.
dc.contributor.authorHall, L. S.
dc.contributor.authorZeng, Y.
dc.contributor.authorGibson, J.
dc.contributor.authorDavies, G.
dc.contributor.authorFernandez-Pujals, A. M.
dc.contributor.authorThomson, P. A.
dc.contributor.authorHayward, C.
dc.contributor.authorSmith, B. H.
dc.contributor.authorHocking, L. J.
dc.contributor.authorPadmanabhan, S.
dc.contributor.authorDeary, I. J.
dc.contributor.authorPorteous, D. J.
dc.contributor.authorNicodemus, K. K.
dc.contributor.authorMcIntosh, A. M.
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2017-08-30T11:00:15Z
dc.date.available2017-08-30T11:00:15Z
dc.date.issued2017-08-15
dc.descriptionThis investigation was supported by the Wellcome Trust 104036/Z/14/Z (STRADL, Stratifying Resilience and Depression Longitudinally). Generation Scotland received core funding from the Chief Scientist Office of the Scottish Government Health Directorate CZD/16/6 and the Scottish Funding Council HR03006. We thank all families, practitioners and the Scottish School of Primary Care involved in the recruitment process as well as the entirety of Generation Scotland team; interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, healthcare assistants and nurses. We are grateful towards the Dr Mortimer and Theresa Sackler foundation for the financial support for this work. This research has been conducted using the UK Biobank resource and we would therefore like to thank all participants and coordinators in this cohort. The UK Biobank study was conducted under generic approval from the NHS National Research Ethics Service (approval letter dated 17 June 2011. Ref 11/NW/0362). Samples from the English Longitudinal Study of Ageing DNA Repository (EDNAR), which receives support from the National Institute on Aging (NIA) and the Economic and Social Research Council (ESRC), were used in this study. We thank contributors and the ELSA participants. IJD is supported by MRC and BBSRC funding to the University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology (MR/K026992/1). Supplementary Information accompanies the paper on the Translational Psychiatry website (http://www.nature.com/tp)en
dc.description.statusPeer revieweden
dc.format.extent9
dc.format.extent414439
dc.identifier107332567
dc.identifier4b2b1b22-a5eb-4750-bb85-a947847d990c
dc.identifier28809859
dc.identifier85042448444
dc.identifier.citationWigmore, E M, Clarke, T-K, Howard, D M, Adams, M J, Hall, L S, Zeng, Y, Gibson, J, Davies, G, Fernandez-Pujals, A M, Thomson, P A, Hayward, C, Smith, B H, Hocking, L J, Padmanabhan, S, Deary, I J, Porteous, D J, Nicodemus, K K & McIntosh, A M 2017, 'Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766)', Translational Psychiatry, vol. 7, no. 8, e1205, pp. 1-9. https://doi.org/10.1038/tp.2017.148en
dc.identifier.doi10.1038/tp.2017.148
dc.identifier.iss8en
dc.identifier.issn2158-3188
dc.identifier.urihttp://hdl.handle.net/2164/9228
dc.identifier.vol7en
dc.language.isoeng
dc.relation.ispartofTranslational Psychiatryen
dc.subjectJournal Articleen
dc.subjectQH426 Geneticsen
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subjectScottish Funding Councilen
dc.subjectHR03006en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K026992/1en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subject.lccQH426en
dc.titleDo regional brain volumes and major depressive disorder share genetic architecture? : A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766)en
dc.typeJournal articleen

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