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Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion

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dc.contributor.authorPradhan, Arnab
dc.contributor.authorAvelar, Gabriela M.
dc.contributor.authorBain, Judith M.
dc.contributor.authorChilders, Delma
dc.contributor.authorPelletier, Chloe
dc.contributor.authorLarcombe, Daniel E.
dc.contributor.authorShekhova, Elena
dc.contributor.authorNetea, Mihai G.
dc.contributor.authorBrown, Gordon D.
dc.contributor.authorErwig, Lars
dc.contributor.authorGow, Neil A. R.
dc.contributor.authorBrown, Alistair J. P.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.date.accessioned2019-12-24T13:30:01Z
dc.date.available2019-12-24T13:30:01Z
dc.date.issued2019-11-22
dc.descriptionData Availability The authors declare that the data supporting the findings of this study are available within the paper (and its supplementary information files). Acknowledgements We are grateful to Raif Yuecel, Linda Duncan, Kimberley Sim and Ailsa Laird in the Iain Fraser Cytometry Centre, and to Kevin MacKenzie, Debbie Wilkinson, Gillian Milne and Lucy Wight in our Microscopy and Histology Core Facility for their superb support. We thank Katja Schafer and Angela Lopez for help with the design of primers and for providing CRISPR-Cas9 protocols for mutant construction. We also thank our colleagues in the Candida community, and in particular Jan Quinn, Guanghua Huang, Suzanne Noble, Karl Kuchler, Patrick van Dijck, Rich Calderone and Malcolm Whiteway for providing strains used in this study. This work was funded by a programme grant from the UK Medical Research Council [www.mrc.ac.uk: MR/M026663/1], and by PhD studentships from the University of Aberdeen to AP, DL. The work was also supported by the Medical Research Council Centre for Medical Mycology and the University of Aberdeen [MR/N006364/1], by the European Commission [FunHoMic: H2020-MSCA-ITN-2018-812969], and by the Wellcome Trust via Investigator, Collaborative, Equipment, Strategic and Biomedical Resource awards [www.wellcome.ac.uk: 075470, 086827, 093378, 097377, 099197, 101873, 102705, 200208]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent2399077
dc.identifier147721277
dc.identifier6144b078-894c-4bbc-9253-89e3d09c94e9
dc.identifier85075522209
dc.identifier.citationPradhan, A, Avelar, G M, Bain, J M, Childers, D, Pelletier, C, Larcombe, D E, Shekhova, E, Netea, M G, Brown, G D, Erwig, L, Gow, N A R & Brown, A J P 2019, 'Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion', Nature Communications, vol. 10, 5315. https://doi.org/10.1038/s41467-019-13298-9en
dc.identifier.doi10.1038/s41467-019-13298-9
dc.identifier.issn2041-1723
dc.identifier.otherORCID: /0000-0003-2869-7332/work/76975994
dc.identifier.otherORCID: /0000-0002-1060-0419/work/112075827
dc.identifier.urihttps://hdl.handle.net/2164/13428
dc.identifier.vol10en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectCandida albicansen
dc.subjectimmune evasionen
dc.subjectcell wallen
dc.subjectpathogen associated molecular patternsen
dc.subjectβ-glucanen
dc.subjectiron responsesen
dc.subjectFtr1en
dc.subjectSef1en
dc.subjectcAMP-protein kinase A signallingen
dc.subjectR Medicine (General)en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/M026663/1en
dc.subjectMR/N006364/1en
dc.subjectEuropean Commissionen
dc.subjectH2020-MSCA-ITN-2018-812969en
dc.subjectWellcome Trusten
dc.subject075470en
dc.subject086827en
dc.subject093378en
dc.subject097377en
dc.subject099197en
dc.subject101873en
dc.subject102705en
dc.subject200208en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleNon-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasionen
dc.typeJournal articleen

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