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Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons

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dc.contributor.authorVirdi, Gurvir S.
dc.contributor.authorChoi, Minee L.
dc.contributor.authorEvans, James R.
dc.contributor.authorYao, Zhi
dc.contributor.authorAthauda, Dilan
dc.contributor.authorStrohbuecker, Stephanie
dc.contributor.authorNirujogi, Raja S.
dc.contributor.authorWernick, Anna I.
dc.contributor.authorPelegrina-Hidalgo, Noelia
dc.contributor.authorLeighton, Craig
dc.contributor.authorSaleeb, Rebecca S.
dc.contributor.authorKopach, Olga
dc.contributor.authorAlrashidi, Haya
dc.contributor.authorMelandri, Daniela
dc.contributor.authorPerez-Lloret, Jimena
dc.contributor.authorAngelova, Plamena R.
dc.contributor.authorSylantyev, Sergiy
dc.contributor.authorEaton, Simon
dc.contributor.authorHeales, Simon
dc.contributor.authorRusakov, Dmitri A.
dc.contributor.authorAlessi, Dario R.
dc.contributor.authorKunath, Tilo
dc.contributor.authorHorrocks, Mathew H.
dc.contributor.authorAbramov, Andrey Y.
dc.contributor.authorPatani, Rickie
dc.contributor.authorGandhi, Sonia
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2023-04-10T15:58:01Z
dc.date.available2023-04-10T15:58:01Z
dc.date.issued2022-11-24
dc.descriptionFunding Open Access funding provided by The Francis Crick Institute. Acknowledgements We would wish to thank the patients for the fibroblast donation. We would also like to thank the Francis Crick Institute Flow Cytometry, Advanced Light Microscopy, Advanced Sequencing, and Bioinformatics and Biostatistics STPs for their help and equipment in conducting and analysing the flow cytometry, fluorescence microscopy, and single-cell RNA-seq experiments. This research was funded in whole or in part by Aligning Science Across Parkinson’s [ASAP-000509 and ASAP-000463] through the Michael J. Fox Foundation for Parkinson’s Research (MJFF). For the purpose of open-access, the author has applied a CC public copyright license to all Author Accepted Manuscripts arising from this submission. G.S.V. acknowledges funding from the UCL-Birkbeck MRC DTP. S.G. acknowledges funding from the i2i G.S. Virdi et al. 21 Published in partnership with the Parkinson’s Foundation npj Parkinson’s Disease (2022) 162 grant (The Francis Crick Institute), MJFox foundation, the Wellcome Trust, and is an MRC Senior Clinical Fellow [MR/T008199/1]. D.A. is funded by the National Institute for Health Research. R.P. holds an MRC Senior Clinical Fellowship [MR/S006591/1] and a Lister Research Prize Fellowship. H.A. acknowledges funding from the Kuwait University, Kuwait. M.H. acknowledges funding from UCB Biopharma, and Dr. Jim Love. N.P. acknowledges funding from Medical Research Scotland [PHD-50193–2020]. This work is supported by the Francis Crick Institute which receives funding from the UK Medical Research Council, Cancer Research UK, and the Wellcome Trust. Research at UCL Great Ormond Street Institute of Child Health benefits from funding from the NIHR Biomedical Research Centre at Great Ormond Street Hospital.en
dc.description.statusPeer revieweden
dc.format.extent22
dc.format.extent5683551
dc.identifier223736875
dc.identifier8527a149-7255-4950-a66d-40eed35f0442
dc.identifier36424392
dc.identifier85142346721
dc.identifier.citationVirdi, G S, Choi, M L, Evans, J R, Yao, Z, Athauda, D, Strohbuecker, S, Nirujogi, R S, Wernick, A I, Pelegrina-Hidalgo, N, Leighton, C, Saleeb, R S, Kopach, O, Alrashidi, H, Melandri, D, Perez-Lloret, J, Angelova, P R, Sylantyev, S, Eaton, S, Heales, S, Rusakov, D A, Alessi, D R, Kunath, T, Horrocks, M H, Abramov, A Y, Patani, R & Gandhi, S 2022, 'Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons', npj Parkinson's Disease, vol. 8, no. 1, 162. https://doi.org/10.1038/s41531-022-00423-7en
dc.identifier.doi10.1038/s41531-022-00423-7
dc.identifier.iss1en
dc.identifier.issn2373-8057
dc.identifier.otherPubMedCentral: PMC9691718
dc.identifier.otherORCID: /0000-0002-1358-0601/work/132961172
dc.identifier.urihttps://hdl.handle.net/2164/20460
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85142346721&partnerID=8YFLogxKen
dc.identifier.vol8en
dc.language.isoeng
dc.relation.ispartofnpj Parkinson's Diseaseen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNeurologyen
dc.subjectClinical Neurologyen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectOtheren
dc.subjectSupplementary Dataen
dc.subject.lccRC0321en
dc.titleProtein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neuronsen
dc.typeJournal articleen

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