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Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps

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dc.contributor.authorHuang, Sheng
dc.contributor.authorElsayed, Somayah Sameer
dc.contributor.authorLv, Meinan
dc.contributor.authorTabudravu, Jioji
dc.contributor.authorRateb, Mostafa E
dc.contributor.authorGyampoh, Roland
dc.contributor.authorKyeremeh, Kwaku
dc.contributor.authorEbel, Rainer
dc.contributor.authorJaspars, Marcel
dc.contributor.authorDeng, Zixin
dc.contributor.authorYu, Yi
dc.contributor.authorDeng, Hai
dc.contributor.institutionUniversity of Aberdeen.Natural & Computing Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.date.accessioned2016-12-18T00:30:10Z
dc.date.available2016-12-18T00:30:10Z
dc.date.embargoedUntil2016-12-17
dc.date.issued2015-12-17
dc.descriptionAcknowledgments Y.Y. acknowledges the financial support from “973” Program (2012CB721006) and National Natural Science Foundation of China (31570033). R.E., K.K., H.D., and M.J. acknowledge the financial support of the Leverhulme Trust-Royal Society Africa Award (AA090088).en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent843679
dc.identifier59328807
dc.identifierf9cce7df-47da-4f82-84e6-84096e13ae81
dc.identifier84950301578
dc.identifier.citationHuang, S, Elsayed, S S, Lv, M, Tabudravu, J, Rateb, M E, Gyampoh, R, Kyeremeh, K, Ebel, R, Jaspars, M, Deng, Z, Yu, Y & Deng, H 2015, 'Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps', Chemistry & Biology, vol. 22, no. 12, pp. 1633-1642. https://doi.org/10.1016/j.chembiol.2015.10.012en
dc.identifier.doi10.1016/j.chembiol.2015.10.012
dc.identifier.iss12en
dc.identifier.issn1074-5521
dc.identifier.otherORCID: /0000-0002-0047-0622/work/159509120
dc.identifier.otherORCID: /0000-0002-2426-6028/work/163664512
dc.identifier.urihttp://hdl.handle.net/2164/7887
dc.identifier.vol22en
dc.language.isoeng
dc.relation.ispartofChemistry & Biologyen
dc.subjectcarbazole alkaloidsen
dc.subjectbiosynthesisen
dc.subjectprenyltransferaseen
dc.subjectreconstitutionen
dc.subjectP450 enzymeen
dc.subjectneocarazostatin Aen
dc.subjectQ Scienceen
dc.subject.lccQen
dc.titleBiosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Stepsen
dc.typeJournal articleen

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