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Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

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dc.contributor.authorZhang, Qian
dc.contributor.authorVallerga, Costanza L
dc.contributor.authorWalker, Rosie M
dc.contributor.authorLin, Tian
dc.contributor.authorHenders, Anjali K
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorHe, Ji
dc.contributor.authorFan, Dongsheng
dc.contributor.authorFowdar, Javed
dc.contributor.authorKennedy, Martin
dc.contributor.authorPitcher, Toni
dc.contributor.authorPearson, John
dc.contributor.authorHalliday, Glenda
dc.contributor.authorKwok, John B
dc.contributor.authorHickie, Ian
dc.contributor.authorLewis, Simon
dc.contributor.authorAnderson, Tim
dc.contributor.authorSilburn, Peter A
dc.contributor.authorMellick, George D
dc.contributor.authorHarris, Sarah E
dc.contributor.authorRedmond, Paul
dc.contributor.authorMurray, Alison D
dc.contributor.authorPorteous, David J
dc.contributor.authorHaley, Christopher S
dc.contributor.authorEvans, Kathryn L
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorYang, Jian
dc.contributor.authorGratten, Jacob
dc.contributor.authorMarioni, Riccardo E
dc.contributor.authorWray, Naomi R
dc.contributor.authorDeary, Ian J
dc.contributor.authorMcRae, Allan F
dc.contributor.authorVisscher, Peter M
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2019-08-26T10:50:08Z
dc.date.available2019-08-26T10:50:08Z
dc.date.issued2019-08-23
dc.descriptionThis research was supported by the Australian Research Council (DP160102400), the Australian National Health and Medical Research Council (1078037, 1078901, 1103418, 1107258, 1127440 and 1113400), and the Sylvia & Charles Viertel Charitable Foundation. Riccardo Marioni was supported by Alzheimer’s Research UK Major Project Grant [ARUK-PG2017B-10]. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006]. Genotyping and DNA methylation profiling of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland, and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” ((STRADL) Reference 104036/Z/14/Z).en
dc.description.statusPeer revieweden
dc.format.extent1310585
dc.identifier147039767
dc.identifier75af0ba5-d725-41dd-be40-c28c68564dc7
dc.identifier31443728
dc.identifier85071444839
dc.identifier000483565300001
dc.identifier.citationZhang, Q, Vallerga, C L, Walker, R M, Lin, T, Henders, A K, Montgomery, G W, He, J, Fan, D, Fowdar, J, Kennedy, M, Pitcher, T, Pearson, J, Halliday, G, Kwok, J B, Hickie, I, Lewis, S, Anderson, T, Silburn, P A, Mellick, G D, Harris, S E, Redmond, P, Murray, A D, Porteous, D J, Haley, C S, Evans, K L, McIntosh, A M, Yang, J, Gratten, J, Marioni, R E, Wray, N R, Deary, I J, McRae, A F & Visscher, P M 2019, 'Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing', Genome Research, vol. 11, 54. https://doi.org/10.1186/s13073-019-0667-1en
dc.identifier.doi10.1186/s13073-019-0667-1
dc.identifier.issn1088-9051
dc.identifier.otherMendeley: 1de4c6b6-317e-3570-a8c5-a7e384f6a541
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976596
dc.identifier.urihttp://hdl.handle.net/2164/12785
dc.identifier.urlhttps://genomemedicine.biomedcentral.com/articles/10.1186/s13073-019-0667-1en
dc.identifier.urlhttp://www.mendeley.com/research/improved-precision-epigenetic-clock-estimates-across-tissues-implication-biological-ageingen
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85071444839&partnerID=8YFLogxKen
dc.identifier.vol11en
dc.language.isoeng
dc.relation.ispartofGenome Researchen
dc.subjectDNA methylationen
dc.subjectage predictionen
dc.subjectepigenetic clocken
dc.subjectEpigenetic clocken
dc.subjectAgeingen
dc.subjectMortalityen
dc.subjectAge predictionen
dc.subjectBIOMARKERSen
dc.subjectCOHORT PROFILEen
dc.subjectDNA METHYLATION AGEen
dc.subjectR Medicineen
dc.subjectGenetics(clinical)en
dc.subjectGeneticsen
dc.subjectMolecular Medicineen
dc.subjectMolecular Biologyen
dc.subjectScottish Funding Councilen
dc.subjectHR03006en
dc.subjectMedical Research Council (MRC)en
dc.subject1078037en
dc.subject1078901en
dc.subject1103418en
dc.subject1107258en
dc.subject1127440en
dc.subject1113400en
dc.subjectArthritis Research UK (ARUK)en
dc.subjectPG2017B-10en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleImproved precision of epigenetic clock estimates across tissues and its implication for biological ageingen
dc.typeJournal articleen

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