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Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro

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dc.contributor.authorMaina, Mahmoud B.
dc.contributor.authorAl-Hilaly, Youssra K.
dc.contributor.authorOakley, Sebastian
dc.contributor.authorBurra, Gunasekhar
dc.contributor.authorKhanom, Tahmida
dc.contributor.authorBiasetti, Luca
dc.contributor.authorMengham, Kurtis
dc.contributor.authorMarshall, Karen
dc.contributor.authorHarrington, Charles R.
dc.contributor.authorWischik, Claude M.
dc.contributor.authorSerpell, Louise C.
dc.contributor.institutionUniversity of Aberdeen.Neuroscienceen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2022-11-10T16:17:00Z
dc.date.available2022-11-10T16:17:00Z
dc.date.issued2022-10-15
dc.descriptionAcknowledgements The authors are grateful to M Goedert (MRC Laboratory of Molecular Biology, Cambridge, UK) for ex-vivo paired helical filaments which were kindly contributed by Bernandino Ghetti (Indiana University, USA). The authors are very grateful to Urmi Sengupta, Nemil Bhatt and Rakez Kayed (University of Texas, USA) for providing ex-vivo tau oligomers. TEM work was performed at the University of Sussex’s Electron microscopy imaging centre (EMC), funded by the School of Life Sciences, the Wellcome Trust (095605/Z/11/A, 208348/Z/17/Z) and the RM Phillips Trust. The authors thank Dr Pascale Schellenberger for valuable support. Funding This work was supported by funding from Alzheimer’s Society [AS-PG-16b-010] awarded to LCS and funding MBM. MBM is funded by the Alzheimer’s Association. YA is supported by WisTa Laboratories Ltd (PAR1596). The work was supported by ARUK South Coast Network. GB was supported by European Molecular Biology Organisation (EMBO) Short-Term Fellowship award (EMBO-STF 7674). LCS is supported by BBSRC [BB/S003657/1]. Urmi Sengupta, Nemil Bhatt, Rakez Kayed acknowledge the funding that supports their contribution (NIH grants to R.K: R01 AG054025 and U24AG072458).en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent2977775
dc.identifier220543950
dc.identifier56855ef0-6574-4ab4-8bac-8e00351c1aec
dc.identifier85136298107
dc.identifier35961386
dc.identifier35961386
dc.identifier35961386
dc.identifier.citationMaina, M B, Al-Hilaly, Y K, Oakley, S, Burra, G, Khanom, T, Biasetti, L, Mengham, K, Marshall, K, Harrington, C R, Wischik, C M & Serpell, L C 2022, 'Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro', Journal of Molecular Biology, vol. 434, no. 19, 167785. https://doi.org/10.1016/j.jmb.2022.167785en
dc.identifier.doi10.1016/j.jmb.2022.167785
dc.identifier.issn0022-2836
dc.identifier.otherORCID: /0000-0003-2250-3920/work/173415913
dc.identifier.urihttps://hdl.handle.net/2164/19515
dc.identifier.urlhttps://www.scopus.com/pages/publications/85136298107en
dc.language.isoeng
dc.relation.ispartofJournal of Molecular Biologyen
dc.subjectAlzheimer's diseaseen
dc.subjectdityrosineen
dc.subjectoxidative stressen
dc.subjectpaired helical filamentsen
dc.subjecttauen
dc.subjectQH301 Biologyen
dc.subjectBiophysicsen
dc.subjectStructural Biologyen
dc.subjectMolecular Biologyen
dc.subject.lccQH301en
dc.titleDityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitroen
dc.typeJournal articleen

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