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Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

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dc.contributor.authorCao, Huan
dc.contributor.authorAntonopoulos, Aristotelis
dc.contributor.authorHenderson, Sadie
dc.contributor.authorWassall, Heather J.h
dc.contributor.authorBrewin, John
dc.contributor.authorMasson, Alanna
dc.contributor.authorShepherd, Jenna
dc.contributor.authorKonieczny, Gabriela
dc.contributor.authorPatel, Bhinal
dc.contributor.authorWilliams, Maria-Louise
dc.contributor.authorDavie, Adam
dc.contributor.authorForrester, Megan Amy
dc.contributor.authorHall, Lindsay Susan
dc.contributor.authorMinter, Beverley
dc.contributor.authorTampakis, Dimitris
dc.contributor.authorMoss, Michael
dc.contributor.authorLennon, Charlotte
dc.contributor.authorPickford, Wendy
dc.contributor.authorErwig, Lars
dc.contributor.authorRobertson, Beverley
dc.contributor.authorDell, Anne
dc.contributor.authorBrown, Gordon
dc.contributor.authorWilson, Heather
dc.contributor.authorRees, David C.
dc.contributor.authorHaslam, Stuart M
dc.contributor.authorRowe, J. Alexandra
dc.contributor.authorBarker, Robert
dc.contributor.authorVickers, Mark
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.date.accessioned2021-03-31T09:18:01Z
dc.date.available2021-03-31T09:18:01Z
dc.date.issued2021-03-19
dc.descriptionAcknowledgements We are grateful for the assistance provided by both the Microscopy and Histology Core Facility, and the Iain Fraser Cytometry Centre, at the University of Aberdeen. We thank Ann Wheeler and Matt Pearson from Edinburgh Super-Resolution Imaging Consortium for technical support with 3D SIM microscopy. We also thank Janet A. Willment and Bernard Kerscher, supervised by G.D.B., for providing the Fc fusion proteins, Jeanette A. Wagener, supervised by Neil A.R.G. Gow, for providing high purity chitin, Jan Westland for obtaining blood samples and Paul Crocker for useful discussions. Principal funding for this project was provided by Wellcome Trust grant 094847 (R.N.B., L.P.E., M.A.V.). In addition, support was provided by Biotechnology and Biological Sciences Research Council grants BBF0083091 (A.D. and S.M.H.) and BBK0161641 (A.D. and S.M.H.), Wellcome Trust grant 082098 (A.D.), Wellcome Trust grants 97377, 102705 (G.D.B.), and funding for the MRC Centre for Medical Mycology at the University of Aberdeen MR/N006364/1 (G.D.B.).en
dc.description.statusPeer revieweden
dc.format.extent13
dc.format.extent3277453
dc.identifier187675853
dc.identifier3adb234f-2907-468f-9c81-5518a45b83fd
dc.identifier33741926
dc.identifier85102890135
dc.identifier000631934100024
dc.identifier.citationCao, H, Antonopoulos, A, Henderson, S, Wassall, H J H, Brewin, J, Masson, A, Shepherd, J, Konieczny, G, Patel, B, Williams, M-L, Davie, A, Forrester, M A, Hall, L S, Minter, B, Tampakis, D, Moss, M, Lennon, C, Pickford, W, Erwig, L, Robertson, B, Dell, A, Brown, G, Wilson, H, Rees, D C, Haslam, S M, Rowe, J A, Barker, R & Vickers, M 2021, 'Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance', Nature Communications, vol. 12, no. 1, 1792. https://doi.org/10.1038/s41467-021-21814-zen
dc.identifier.doi10.1038/s41467-021-21814-z
dc.identifier.iss1en
dc.identifier.issn2041-1723
dc.identifier.otherORCID: /0000-0002-1407-7274/work/91891237
dc.identifier.otherORCID: /0000-0002-3154-1040/work/91891820
dc.identifier.urihttps://hdl.handle.net/2164/16159
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85102890135&partnerID=8YFLogxKen
dc.identifier.vol12en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectGlycobiologyen
dc.subjectMalariaen
dc.subjectPattern recognition receptorsen
dc.subjectsickle cell diseaseen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subject094847en
dc.subject082098en
dc.subject97377en
dc.subject102705en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBBF0083091en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleRed blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistanceen
dc.typeJournal articleen

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