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Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease : Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

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dc.contributor.authorWilcock, Gordon K
dc.contributor.authorGauthier, Serge
dc.contributor.authorFrisoni, Giovanni B
dc.contributor.authorJia, Jianping
dc.contributor.authorHardlund, Jiri H
dc.contributor.authorMoebius, Hans J
dc.contributor.authorBentham, Peter
dc.contributor.authorKook, Karin A
dc.contributor.authorSchelter, Bjoern Olaf
dc.contributor.authorWischik, Damon J
dc.contributor.authorDavis, Charles S
dc.contributor.authorStaff, Roger T
dc.contributor.authorVuksanovic, Vesna
dc.contributor.authorAhearn, Trevor
dc.contributor.authorBracoud, Luc
dc.contributor.authorShamsi, Kohkan
dc.contributor.authorMarek, Ken
dc.contributor.authorSeibyl, John
dc.contributor.authorRiedel, Gernot
dc.contributor.authorStorey, John M. D.
dc.contributor.authorHarrington, Charles R
dc.contributor.authorWischik, Claude M
dc.contributor.institutionUniversity of Aberdeen.Physicsen
dc.contributor.institutionUniversity of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB)en
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.date.accessioned2017-12-06T17:43:23Z
dc.date.available2017-12-06T17:43:23Z
dc.date.issued2017-11-28
dc.descriptionThe supplementary material is available in the electronic version of this article: http://dx.doi.org/10.3233/JAD-170560. The study was sponsored by TauRx Therapeutics (Singapore). We thank Lon Schneider and Howard Feldman for their contribution to the Scientific Advisory Board. We gratefully acknowledge study investigators and the generosity of study participants. Authors’ disclosures available online (http://j-alz.com/manuscript disclosures/17-0560r3).en
dc.description.statusPeer revieweden
dc.format.extent24
dc.format.extent1832124
dc.identifier108289857
dc.identifier6ed5919c-278e-4174-ac1f-456eb22145a6
dc.identifier85036556784
dc.identifier.citationWilcock, G K, Gauthier, S, Frisoni, G B, Jia, J, Hardlund, J H, Moebius, H J, Bentham, P, Kook, K A, Schelter, B O, Wischik, D J, Davis, C S, Staff, R T, Vuksanovic, V, Ahearn, T, Bracoud, L, Shamsi, K, Marek, K, Seibyl, J, Riedel, G, Storey, J M D, Harrington, C R & Wischik, C M 2017, 'Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease : Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial', Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457. https://doi.org/10.3233/JAD-170560en
dc.identifier.doi10.3233/JAD-170560
dc.identifier.iss1en
dc.identifier.issn1387-2877
dc.identifier.otherORCID: /0000-0002-5261-5467/work/73579133
dc.identifier.otherORCID: /0000-0003-2250-3920/work/47672895
dc.identifier.urihttp://hdl.handle.net/2164/9693
dc.identifier.urlhttps://www.j-alz.com/vol61-1en
dc.identifier.vol61en
dc.language.isoeng
dc.relation.ispartofJournal of Alzheimer's Diseaseen
dc.subjectADAS-cogen
dc.subjectAlzheimer’s diseaseen
dc.subjectamyloid proteinen
dc.subjectclinical trialen
dc.subjectcohort studyen
dc.subjectmethylthioniniumen
dc.subjecttau proteinen
dc.subjecttreatmenten
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subject.lccRC0321en
dc.titlePotential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease : Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trialen
dc.typeJournal articleen

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