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Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

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dc.contributor.authorPollack, Saskia J.
dc.contributor.authorTrigg, Jasmine
dc.contributor.authorKhanom, Tahmida
dc.contributor.authorBiasetti, Luca
dc.contributor.authorMarshall, Karen E.
dc.contributor.authorAl-Hilaly, Youssra K.
dc.contributor.authorRickard, Janet E.
dc.contributor.authorHarrington, Charles R.
dc.contributor.authorWischik, Claude M.
dc.contributor.authorSerpell, Louise C.
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.date.accessioned2020-08-04T17:50:00Z
dc.date.available2020-08-04T17:50:00Z
dc.date.issued2020-08-07
dc.descriptionAcknowledgements The authors wish to thank Dr Pascale Schellenberger for technical help with transmission electron microscopy. The authors are grateful for valuable experimental support from Dr Mahmoud Bukar Maina. SJP was supported by a Sussex Neuroscience doctoral grant. KEM was supported by Medical Research Council (MR/K022105/1) awarded to LCS. LCS is supported by funding from Alzheimer’s Research UK and Alzheimer’s Society and Biotechnology and Biological Sciences Research Council (BB/S003657/1) Funding SJP was supported by a Sussex Neuroscience doctoral grant. KEM was supported by Medical Research Council (MR/K022105/1) awarded to LCS. LCS is supported by funding from Alzheimer’s Research UK and Alzheimer’s Society and Biotechnology and Biological Sciences Research Council (BB/S003657/1). KEM and YKA were supported by funding from WisTa Laboratories Ltd. (PAR1596).en
dc.description.statusPeer revieweden
dc.format.extent17
dc.format.extent3386947
dc.identifier170338805
dc.identifiera5fb045d-38a7-41cb-8213-ca7b5d9ce3f0
dc.identifier85088780669
dc.identifier32681841
dc.identifier000557764100009
dc.identifier.citationPollack, S J, Trigg, J, Khanom, T, Biasetti, L, Marshall, K E, Al-Hilaly, Y K, Rickard, J E, Harrington, C R, Wischik, C M & Serpell, L C 2020, 'Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells', Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907. https://doi.org/10.1016/j.jmb.2020.05.027en
dc.identifier.doi10.1016/j.jmb.2020.05.027
dc.identifier.iss17en
dc.identifier.issn0022-2836
dc.identifier.otherORCID: /0000-0003-2250-3920/work/173415879
dc.identifier.urihttps://hdl.handle.net/2164/14862
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85088780669&partnerID=8YFLogxKen
dc.identifier.vol432en
dc.language.isoeng
dc.relation.ispartofJournal of Molecular Biologyen
dc.subjecttauen
dc.subjectAlzheimer’s diseaseen
dc.subjectpropagationen
dc.subjectaggregationen
dc.subjectAlzheimer's diseaseen
dc.subjectALZHEIMERS-DISEASEen
dc.subjectTAUOPATHYen
dc.subjectPATHOLOGYen
dc.subjectAUTOPHAGYen
dc.subjectOLIGOMERSen
dc.subjectIN-VITROen
dc.subjectFIBRILSen
dc.subjectPROPAGATIONen
dc.subjectAGGREGATIONen
dc.subjectSYNTHETIC TAUen
dc.subjectR Medicine (General)en
dc.subjectMolecular Biologyen
dc.subjectStructural Biologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/K022105/1en
dc.subjectAlzheimers Research UKen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/S003657/1en
dc.subject.lccR1en
dc.titlePaired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cellsen
dc.typeJournal articleen

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