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Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

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dc.contributor.authorSchelter, Bjoern O.
dc.contributor.authorShiells, Helen
dc.contributor.authorBaddeley, Thomas C.
dc.contributor.authorRubino, Christopher M.
dc.contributor.authorGanesan, Harish
dc.contributor.authorHammel, Jeffrey
dc.contributor.authorVuksanovic, Vesna
dc.contributor.authorStaff, Roger T.
dc.contributor.authorMurray, Alison D.
dc.contributor.authorBracoud, Luc
dc.contributor.authorRiedel, Gernot
dc.contributor.authorGauthier, Serge
dc.contributor.authorJia, Jianping
dc.contributor.authorBentham, Peter
dc.contributor.authorKook, Karin
dc.contributor.authorStorey, John M. D.
dc.contributor.authorHarrington, Charles R.
dc.contributor.authorWischik, Claude M.
dc.contributor.institutionUniversity of Aberdeen.Physicsen
dc.contributor.institutionUniversity of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB)en
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2019-12-02T15:00:02Z
dc.date.available2019-12-02T15:00:02Z
dc.date.issued2019-11-26
dc.descriptionACKNOWLEDGMENTS We gratefully acknowledge study investigators and the generosity of study participants. We gratefully acknowledge Professor Gordon Wilcock for critical review and commentary on drafts of the manuscript. Author’s disclosures available online (https://www.j-alz.com/manuscript-disclosures/19-0772r1). SUPPLEMENTARY MATERIAL The supplementary material is available in the electronic version of this article: http://dx.doi.org/10.3233/JAD-190772. Availability of data and materials The datasets and analyses used during the current study are available from the corresponding author on reasonable request.en
dc.description.statusPeer revieweden
dc.format.extent16
dc.format.extent762527
dc.identifier147850840
dc.identifiera775ea10-3075-4706-8691-4c38907acdbe
dc.identifier31658058
dc.identifier85075885164
dc.identifier.citationSchelter, B O, Shiells, H, Baddeley, T C, Rubino, C M, Ganesan, H, Hammel, J, Vuksanovic, V, Staff, R T, Murray, A D, Bracoud, L, Riedel, G, Gauthier, S, Jia, J, Bentham, P, Kook, K, Storey, J M D, Harrington, C R & Wischik, C M 2019, 'Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease', Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946. https://doi.org/10.3233/JAD-190772en
dc.identifier.doi10.3233/JAD-190772
dc.identifier.iss3en
dc.identifier.issn1387-2877
dc.identifier.otherORCID: /0000-0002-5261-5467/work/73579158
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976621
dc.identifier.otherORCID: /0000-0003-2250-3920/work/173415902
dc.identifier.urihttps://hdl.handle.net/2164/13339
dc.identifier.vol72en
dc.language.isoeng
dc.relation.ispartofJournal of Alzheimer's Diseaseen
dc.subjectAcetylcholinesterase inhibitoren
dc.subjectAlzheimer’s diseaseen
dc.subjectclinical trialsen
dc.subjectdrug interactionen
dc.subjectleucomethylthioniniumen
dc.subjectpopulation pharmacokineticsen
dc.subjecthydromethylthionineen
dc.subjectR Medicine (General)en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleConcentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Diseaseen
dc.typeJournal articleen

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