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Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

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dc.contributor.authorAvgustinova, Alexandra
dc.contributor.authorIravani, Marjan
dc.contributor.authorRobertson, David
dc.contributor.authorFearns, Antony
dc.contributor.authorGao, Qiong
dc.contributor.authorKlingbeil, Pamela
dc.contributor.authorHanby, Andrew M
dc.contributor.authorSpeirs, Valerie
dc.contributor.authorSahai, Erik
dc.contributor.authorCalvo, Fernando
dc.contributor.authorIsacke, Clare M
dc.date.accessioned2018-07-20T15:48:04Z
dc.date.available2018-07-20T15:48:04Z
dc.date.issued2016-01-18
dc.descriptionThis work was funded by Breakthrough Breast Cancer (recently merged with Breast Cancer Campaign forming Breast Cancer Now; C.M.I.), Cancer Research UK (A.A., E.S. and CMI) and Breast Cancer Campaign (V.S. and A.H.). F.C. is currently funded by The Institute of Cancer Research and Worldwide Cancer Research. We acknowledge NHS funding to the NIHR Biomedical Research Centre at The Royal Marsden and the ICR. We thank the Breakthrough Histopathology Facility, Cambridge Genomic Services for the gene expression analysis, Balazs Gyorffy for providing the clinical breast cancer outcome data, Antoinette van Weverwijk for help with the in vivo assays, Fredrik Wallberg for help with the FACSorting, Andrea Morandi for help with the TMA analysis, Patricia Salinas for the Wnt7a cDNA construct and helpful discussions and Lorenzo Melchor for the pDEST/pHIV-H2BmRFP-rfa_verB Gateway cloning vector.en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent4000601
dc.identifier129546814
dc.identifiera0bffde8-73e3-4ceb-9564-54e053d6a112
dc.identifier26777421
dc.identifier84954525154
dc.identifier.citationAvgustinova, A, Iravani, M, Robertson, D, Fearns, A, Gao, Q, Klingbeil, P, Hanby, A M, Speirs, V, Sahai, E, Calvo, F & Isacke, C M 2016, 'Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness', Nature Communications, vol. 7, 10305. https://doi.org/10.1038/ncomms10305en
dc.identifier.doi10.1038/ncomms10305
dc.identifier.issn2041-1723
dc.identifier.otherPubMedCentral: PMC4735631
dc.identifier.otherORCID: /0000-0002-0602-4666/work/72631293
dc.identifier.urihttp://hdl.handle.net/2164/10774
dc.identifier.vol7en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAnimalsen
dc.subjectBreast Neoplasmsen
dc.subjectFemaleen
dc.subjectFibroblastsen
dc.subjectGene Expression Regulation, Neoplasticen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectNIH 3T3 Cellsen
dc.subjectWnt Proteinsen
dc.subjectJournal Articleen
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectR Medicineen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleTumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressivenessen
dc.typeJournal articleen

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